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  • 产品名称：TransformingGrowthFactor,betaReceptorII(70/80kDa)(TGFBR2)(AA23-159)(Active)prot

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  • 产品厂商：ACROBiosystems
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简单介绍：
TransformingGrowthFactor,betaReceptorII(70/80kDa)(TGFBR2)(AA23-159)(Active)protein(FcTag)
详情介绍：
Characteristics This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 42 kDa. The protein migrates as 55-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background TGF-beta receptor type-2 (TGFBR2 or TGFR-2) is also known as TGF-beta type II receptor, Transforming growth factor-beta receptor type II, TbetaR-II, TGFβR2, which is a homodimer or heterohexamer, belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family and TGFB receptor subfamily. TGFR2 / TGFBR2 binds TGF-β1 / TGFB1 and TGF-β3 / TGFB3 with high affinity and TGF-β2 / TGFB2 with a much lower affinity. This type I I receptor forms a heterodimeric complex with type I receptor and is essential for signal transduction. Upon ligand binding, the TGFR2 autophosphorylates its cytoplasmic domain and subsequently phosphorylates the downstream molecules which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation.
Molecular Weight 42 kDa
NCBI Accession NP_003233
UniProt P37173
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 50 mM Tris, 100 mM Glycine, pH 7.5
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Transforming Growth Factor, beta Receptor II (70/80kDa) (TGFBR2) (AA 23-159) (Active) protein (Fc Tag) (ABIN2181811) Human TGF-beta RII, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stai...
Background publications Kaplan, Xu, Feldman, Brown, Cho, Choi, Connor, Delai, Economides, Glaser, Groppe, Katagiri, Le Merrer, Morhart, Ravazzolo, Rogers, Smith, Triffitt, Urtizberea, Zasloff, Shore: "Response to "Mutations of the NOGGIN and of the activin A type I receptor genes in fibrodysplasia ossificans progressiva (FOP)" by Lucotte et al." in: Genetic counseling (Geneva, Switzerland), Vol. 19, Issue 3, pp. 357-9; author reply 361-3, 2008 (PubMed).

Deep, Walker, Shu, Hinck: "Solution structure and backbone dynamics of the TGFbeta type II receptor extracellular domain." in: Biochemistry, Vol. 42, Issue 34, pp. 10126-39, 2003 (PubMed).

Wieser, Wrana, Massagué: "GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex." in: The EMBO journal, Vol. 14, Issue 10, pp. 2199-208, 1995 (PubMed).