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  • 产品名称：Angiotensinogen(serpinPeptidaseInhibitor,CladeA,Member8)(AGT)(AA34-485)(Active)

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  • 产品厂商：ACROBiosystems
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简单介绍：
Angiotensinogen(serpinPeptidaseInhibitor,CladeA,Member8)(AGT)(AA34-485)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 50.6 kDa. The protein migrates as 55-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >98 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Serpin A8 also known as angiotensinogen (AGT) , is a member of the serpin family. It is an α-2-globulin that is expressed by the liver and secreted in plasma. As essential component of the renin-angiotensin system (RAS), Angiotensinogen is cleaved into three chains: Angiotensin-1 (Ang I), Angiotensin-2 (Ang II), and Angiotensin-3 (Ang III) in lowered blood pressure by the enzyme renin. Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2. Angiotensin-2 acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone. Angiotensin-3 stimulates aldosterone release. Defects in AGT are a cause of renal tubular dysgenesis (RTD).
Molecular Weight 50.6 kDa
NCBI Accession NP_000020
UniProt P01019
Pathways JAK-STAT Signaling, ACE Inhibitor Pathway, EGFR Signaling Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Regulation of Lipid Metabolism by PPARalpha, Protein targeting to Nucleus, Feeding Behaviour, Monocarboxylic Acid Catabolic Process, Dicarboxylic Acid Transport, Positive Regulation of Response to DNA Damage Stimulus, Regulation of long-term Neuronal Synaptic Plasticity
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
Supplier Images
SDS-PAGE (SDS) image for Angiotensinogen (serpin Peptidase Inhibitor, Clade A, Member 8) (AGT) (AA 34-485) (Active) protein (His tag) (ABIN2181742) Human Serpin A8, His Tag on SDS-PAGE under reducing (R) condition. The gel was staine...
Background publications Olsen, Wachtell, Beevers, Dahlöf, Devereux, de Faire, Fyhrquist, Ibsen, Kjeldsen, Lederballe-Pedersen, Lindholm, Narayan, Nieminen, Omvik, Oparil, Wedel: "Prognostic importance of hemoglobin in hypertensive patients with electrocardiographic left ventricular hypertrophy: the Losartan Intervention For End point reduction in hypertension (LIFE) study." in: American heart journal, Vol. 157, Issue 1, pp. 177-84, 2008 (PubMed).

Fyhrquist, Saijonmaa: "Renin-angiotensin system revisited." in: Journal of internal medicine, Vol. 264, Issue 3, pp. 224-36, 2008 (PubMed).

Jankowski, Vanholder, van der Giet, Tölle, Karadogan, Gobom, Furkert, Oksche, Krause, Tran, Tepel, Schuchardt, Schlüter, Wiedon, Beyermann, Bader, Todiras, Zidek, Jankowski: "Mass-spectrometric identification of a novel angiotensin peptide in human plasma." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 27, Issue 2, pp. 297-302, 2007 (PubMed).

Weir, Dzau: "The renin-angiotensin-aldosterone system: a specific target for hypertension management." in: American journal of hypertension, Vol. 12, Issue 12 Pt 3, pp. 205S-213S, 2000 (PubMed).

Goodfriend, Peach: "Angiotensin III: (DES-Aspartic Acid-1)-Angiotensin II. Evidence and speculation for its role as an important agonist in the renin - angiotensin system." in: Circulation research, Vol. 36, Issue 6 Suppl 1, pp. 38-48, 1975 (PubMed).