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  • 产品名称：TYRO3ProteinTyrosineKinase(TYRO3)(AA41-428)(Active)protein(FcTag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
TYRO3ProteinTyrosineKinase(TYRO3)(AA41-428)(Active)protein(FcTag)
详情介绍：
Characteristics This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 68.2 kDa. The protein migrates as 85-110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
ProductDetails: Biological Activity Comment Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized rh TYRO3 / DTK Fc Chimera at 2 μg/mL (100 μL/well) can bind rhGas6 with a linear range of 10 - 100 ng/mL.
Background Tyrosine-protein kinase receptor TYRO3 is also known as Tyrosine-protein kinase BYK, DTK, RSE, SKY, TIF, which belongs to the protein kinase superfamily, Tyr protein kinase family and AXL/UFO subfamily. TYRO3 regulates many physiological processes including cell survival, migration and differentiation. TYRO3 activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 interacts (via N-terminus) with extracellular ligands TULP1 and GAS6 By similarity and also interacts with PIK3R1, this interaction increases PI3-kinase activity.
Molecular Weight 68.2 kDa
UniProt Q06418
Research Area Signaling, Tyrosine Kinases
Pathways RTK Signaling
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 50 mM Tris, 100 mM Glycine, pH 7.5
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for TYRO3 Protein Tyrosine Kinase (TYRO3) (AA 41-428) (Active) protein (Fc Tag) (ABIN2181883) Human TYRO3, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained ove...
Background publications Cosemans, Van Kruchten, Olieslagers, Schurgers, Verheyen, Munnix, Waltenberger, Angelillo-Scherrer, Hoylaerts, Carmeliet, Heemskerk: "Potentiating role of Gas6 and Tyro3, Axl and Mer (TAM) receptors in human and murine platelet activation and thrombus stabilization." in: Journal of thrombosis and haemostasis : JTH, Vol. 8, Issue 8, pp. 1797-808, 2010 (PubMed).

Shimojima, Takada, Ebihara, Neumann, Fujioka, Irimura, Jones, Feldmann, Kawaoka: "Tyro3 family-mediated cell entry of Ebola and Marburg viruses." in: Journal of virology, Vol. 80, Issue 20, pp. 10109-16, 2006 (PubMed).

Heiring, Dahlbäck, Muller: "Ligand recognition and homophilic interactions in Tyro3: structural insights into the Axl/Tyro3 receptor tyrosine kinase family." in: The Journal of biological chemistry, Vol. 279, Issue 8, pp. 6952-8, 2004 (PubMed).