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  • 产品名称：IntercellularAdhesionMolecule2(ICAM2)(AA22-223)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
IntercellularAdhesionMolecule2(ICAM2)(AA22-223)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 23.3 kDa. The protein migrates as 40-63 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Intercellular adhesion molecule 2 (ICAM2) is also known as CD antigen CD102, which belongs to the immunoglobulin superfamily and ICAM family. ICAM2 contains two Ig-like C2-type (immunoglobulin-like) domains. ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 / CD102 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.
Molecular Weight 23.3 kDa
NCBI Accession NP_000864
UniProt P13598
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Intercellular Adhesion Molecule 2 (ICAM2) (AA 22-223) (Active) protein (His tag) (ABIN2181239) Human ICAM-2, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained o...
Background publications Xu, Shin, Jaffrey: "Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 46, pp. 19310-5, 2009 (PubMed).

Schiess, Wollscheid, Aebersold: "Targeted proteomic strategy for clinical biomarker discovery." in: Molecular oncology, Vol. 3, Issue 1, pp. 33-44, 2009 (PubMed).

Wollscheid, Bausch-Fluck, Henderson, OBrien, Bibel, Schiess, Aebersold, Watts: "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins." in: Nature biotechnology, Vol. 27, Issue 4, pp. 378-86, 2009 (PubMed).

Liu, Qian, Gritsenko, Camp, Monroe, Moore, Smith: "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." in: Journal of proteome research, Vol. 4, Issue 6, pp. 2070-80, 2005 (PubMed).