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  • 产品名称：TumorNecrosisFactorReceptorSuperfamily,Member10d,DecoywithTruncatedDeathDomain(

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  • 产品厂商：ACROBiosystems
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简单介绍：
TumorNecrosisFactorReceptorSuperfamily,Member10d,DecoywithTruncatedDeathDomain(TNFRSF10D)(AA56-211)(Active)protein(FcTag)
详情介绍：
Characteristics This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 43.4 kDa. The protein migrates as 50-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Tumor necrosis factor receptor superfamily member 10D (TNFRSF10D) is also known as Decoy receptor 2 (DcR2), TNF-related apoptosis-inducing ligand receptor 4 (TRAIL receptor 4 or TRAIL-R4), CD264,which is the single-pass type I membrane protein. TNFRSF10D is receptor for the cytotoxic ligand TRAIL, which contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis.
Molecular Weight 43.4 kDa
NCBI Accession NP_003831
UniProt Q9UBN6
Pathways Apoptosis
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 50 mM Tris, 100 mM Glycine, pH 7.5
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy with Truncated Death Domain (TNFRSF10D) (AA 56-211) (Active) protein (Fc Tag) (ABIN2181844) Human TRAIL R4, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained ...
Background publications Marsters, Sheridan, Pitti, Huang, Skubatch, Baldwin, Yuan, Gurney, Goddard, Godowski, Ashkenazi: "A novel receptor for Apo2L/TRAIL contains a truncated death domain." in: Current biology : CB, Vol. 7, Issue 12, pp. 1003-6, 1998 (PubMed).

Degli-Esposti, Dougall, Smolak, Waugh, Smith, Goodwin: "The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain." in: Immunity, Vol. 7, Issue 6, pp. 813-20, 1998 (PubMed).

Pan, Ni, Yu, Wei, Dixit: "TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling." in: FEBS letters, Vol. 424, Issue 1-2, pp. 41-5, 1998 (PubMed).