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  • 产品名称：Interleukin2Receptor,beta(IL2RB)(AA27-239)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
Interleukin2Receptor,beta(IL2RB)(AA27-239)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 25.4 kDa. The protein migrates as 40 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >90 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
ProductDetails: Biological Activity Comment Biological Activity: Measured by its ability to inhibit the IL-15-dependent proliferation of MO7e human megakaryocytic leukemic cells. The ED50 for this effect is typically 0.5 - 2.5 μg/mL in the presence of 4.0 ng/mL of recombinant human IL-15.
Background Interleukin-2 receptor (IL-2R) is a heterotrimeric protein expressed on the surface of certain immune cells, such as lymphocytes, that binds and responds to a cytokine called IL-2. The IL-2R is made up of 3 subunits - α (CD25), β (CD122) and γ (CD132) - non-covalently associating. The α and β chains are involved in binding IL-2, while signal transduction following cytokine interaction is carried out by the γ-chain, along with the β subunit. CD122 is also known as IL2R beta, is a member of the type I cytokine receptor family. CD122 is the receptor for interleukin-2 and is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2.
Molecular Weight 25.4 kDa
NCBI Accession NP_000869
UniProt P14784
Pathways JAK-STAT Signaling, Growth Factor Binding
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
Supplier Images
SDS-PAGE (SDS) image for Interleukin 2 Receptor, beta (IL2RB) (AA 27-239) (Active) protein (His tag) (ABIN2181385) Interleukin 2 Receptor, beta (IL2RB) (AA 27-239) (Active) protein (His tag)
Background publications Lindholm: "IL-2 receptor signaling through the Shb adapter protein in T and NK cells." in: Biochemical and biophysical research communications, Vol. 296, Issue 4, pp. 929-36, 2002 (PubMed).

Mulloy, Crownley, Fullen, Leonard, Franchini: "The human T-cell leukemia/lymphotropic virus type 1 p12I proteins bind the interleukin-2 receptor beta and gammac chains and affects their expression on the cell surface." in: Journal of virology, Vol. 70, Issue 6, pp. 3599-605, 1996 (PubMed).