Interferon(Alpha,betaandOmega)Receptor1(IFNAR1)(AA28-436)(Active)protein(FcTag) 抗体网

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产品名称：Interferon(Alpha,betaandOmega)Receptor1(IFNAR1)(AA28-436)(Active)protein(FcTag)
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产品厂商：ACROBiosystems
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简单介绍：

Interferon(Alpha,betaandOmega)Receptor1(IFNAR1)(AA28-436)(Active)protein(FcTag)

详情介绍：

Product details
Product details
Characteristics	This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 73.8 kDa. The protein migrates as 110-120 kDa under reducing (R) condition (SDS-PAGE) due to Glycosylation.
Purity	85 % (rh IFNAR1 /IFNAR Fc Chimera) and 13 % (Human IgG1 Fc fragment) as determined by SDS-PAGE.
Sterility	0.22 μm filtered
Endotoxin Level	Less than 1.0 EU per μg by the LAL method.

Target details
Target details
Background	Interferon alpha/beta receptor 1 ( IFNAR1) is also known as Cytokine receptor class-II member 1, Cytokine receptor family 2 member 1 (CRF2-1), Type I interferon receptor 1, IFNAR, which belongs to the type II cytokine receptor family. IFNAR1 /IFNAR contains four fibronectin type-III domains. IFNAR1 associates with IFNAR2 to form the type I interferon receptor. IFNAR1 is receptor for interferons alpha and beta. IFNAR1 can transduce IFNB signals without the help of IFNAR2, and not activating the Jak-STAT pathway.
Molecular Weight	73.8 kDa
NCBI Accession	NP_000620
UniProt	P17181
Pathways	JAK-STAT Signaling, Hepatitis C

Application Details
Application Details
Restrictions	For Research Use only

Handling
Handling
Format	Lyophilized
Reconstitution	Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer	50 mM Tris, 100 mM Glycine, pH 7.5
Handling Advice	Avoid repeated freeze-thaw cycles.
Storage	-20 °C
Storage Comment	No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).

Images
Images
Supplier Images	Human IFN-alpha/beta R1, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was... Human IFN-alpha/beta R1, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is 85% of rh IFNAR1 /IFNAR and 13% of Human IgG1 Fc fragment. Human IFN-alpha/beta R1, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is 85% of rh IFNAR1 /IFNAR and 13% of Human IgG1 Fc fragment.

References
References
Background publications	Russell-Harde, Wagner, Perez, Croze et al.: "Formation of a uniquely stable type I interferon receptor complex by interferon beta is dependent upon particular interactions between interferon beta and its receptor and independent of tyrosine ..." in: Biochemical and biophysical research communications, Vol. 255, Issue 2, pp. 539-44, 1999 (PubMed). Li, Leung, Kerr, Stark: "Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling." in: Molecular and cellular biology, Vol. 17, Issue 4, pp. 2048-56, 1997 (PubMed). Colamonici, Yan, Domanski, Handa, Smalley, Mullersman, Witte, Krishnan, Krolewski: "Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase." in: Molecular and cellular biology, Vol. 14, Issue 12, pp. 8133-42, 1994 (PubMed).