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  • 产品名称：TumorNecrosisFactorReceptorSuperfamily,Member18(TNFRSF18)(AA26-161)(Active)prot

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  • 产品厂商：ACROBiosystems
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简单介绍：
TumorNecrosisFactorReceptorSuperfamily,Member18(TNFRSF18)(AA26-161)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 15.4 kDa. The protein migrates as 22-25 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >92 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
ProductDetails: Biological Activity Comment Biological Activity: Measured by its binding ability with rhGITR Ligand in a functional ELISA.

SDS-PAGE: due to glycosylation.
Background Glucocorticoid-induced TNFR-related protein (GITR) is also known as Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), activation-inducible TNFR family receptor (AITR), CD antigen CD357, which is a member of the tumor necrosis factor receptor (TNF-R) superfamily. GITR is receptor for TNFSF18, which seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR also mediated NF-kappa-B activation via the TRAF2/NIK pathway.
Molecular Weight 15.4 kDa
UniProt Q9Y5U5
Research Area Growth Factors
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18) (AA 26-161) (Active) protein (His tag) (ABIN2181162) Human GITR, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained ove...
Binding Studies (Bind) image for Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18) (AA 26-161) (Active) protein (His tag) (ABIN2181162) Immobilized Human GITR, His Tag (Cat# GIR-H5228) at 2 μg/mL (100 μl/well) can bind Hu...
Background publications Gurney, Marsters, Huang, Pitti, Mark, Baldwin, Gray, Dowd, Brush, Heldens, Schow, Goddard, Wood, Baker, Godowski, Ashkenazi: "Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR." in: Current biology : CB, Vol. 9, Issue 4, pp. 215-8, 1999 (PubMed).