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  • 产品名称：ReceptorTyrosineKinase-LikeOrphanReceptor1(ROR1)(AA30-403)(Active)protein(Hista

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  • 产品厂商：ACROBiosystems
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简单介绍：
ReceptorTyrosineKinase-LikeOrphanReceptor1(ROR1)(AA30-403)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 43.5 kDa. The protein migrates as 55-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Tyrosine-protein kinase transmembrane receptor ROR1 is also known as Neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), which belongs to the protein kinase superfamily or tyr protein kinase family or ROR subfamily. ROR1 contains 1 FZ (frizzled) domain, 1 Ig-like C2-type (immunoglobulin-like) domain, 1 kringle domain, 1 protein kinase domain. ROR1 is expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in ***** tissues. Isoform Short is strongly expressed in fetal and ***** CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm. ROR1 could interact with casein kinase 1 epsilon (CK1ε) to activate phosphoinositide 3-kinase-mediated AKT phosphorylation and cAMP-response-element-binding protein (CREB), which was associated with enhanced tumor-cell growth.
Molecular Weight 43.5 kDa
UniProt Q01973
Research Area Neurology, Tyrosine Kinases
Pathways RTK Signaling, WNT Signaling, Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1) (AA 30-403) (Active) protein (His tag) (ABIN2181697) Human ROR1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained ove...
Background publications Greenman, Stephens, Smith, Dalgliesh, Hunter, Bignell, Davies, Teague, Butler, Stevens, Edkins, OMeara, Vastrik, Schmidt, Avis, Barthorpe, Bhamra, Buck, Choudhury, Clements, Cole, Dicks, Forbes, Gray et al.: "Patterns of somatic mutation in human cancer genomes. ..." in: Nature, Vol. 446, Issue 7132, pp. 153-8, 2007 (PubMed).

Reddy, Phatak, Pleasure: "Human neural tissues express a truncated Ror1 receptor tyrosine kinase, lacking both extracellular and transmembrane domains." in: Oncogene, Vol. 13, Issue 7, pp. 1555-9, 1996 (PubMed).

Muccio, Brouillette, Alam, Vaezi, Sani, Venepally, Reddy, Li, Norris, Simpson-Herren, Hill: "Conformationally defined 6-s-trans-retinoic acid analogs. 3. Structure-activity relationships for nuclear receptor binding, transcriptional activity, and cancer chemopreventive activity." in: Journal of medicinal chemistry, Vol. 39, Issue 19, pp. 3625-35, 1996 (PubMed).

Masiakowski, Carroll: "A novel family of cell surface receptors with tyrosine kinase-like domain." in: The Journal of biological chemistry, Vol. 267, Issue 36, pp. 26181-90, 1993 (PubMed).