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  • 产品名称：Teratocarcinoma-DerivedGrowthFactor1(TDGF1)(AA31-172)(Active)protein(FcTag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
Teratocarcinoma-DerivedGrowthFactor1(TDGF1)(AA31-172)(Active)protein(FcTag)
详情介绍：
Characteristics This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 42.6 kDa. The protein migrates as 44-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >92 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Teratocarcinoma-derived growth factor 1 (TDGF1) is also known as Cripto-1 growth factor (CRGF), Epidermal growth factor-like cripto protein CR1, CRIPTO, is a cell membrane which contains one EGF-like domain. TDGF1 is preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts. TDGF1 interacts with the activin type-1 receptor ACVR1B. TDGF1 could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm.
Molecular Weight 42.6 kDa
NCBI Accession NP_003203
UniProt P13385
Pathways EGFR Signaling Pathway
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 50 mM Tris, 100 mM Glycine, pH 7.5
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Teratocarcinoma-Derived Growth Factor 1 (TDGF1) (AA 31-172) (Active) protein (Fc Tag) (ABIN2180905) Human TDGF1, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained ove...
Background publications Sun, Orozco, Olson, Choi, Garber, Tizard, Szak, Sanicola, Carulli: "CRIPTO3, a presumed pseudogene, is expressed in cancer." in: Biochemical and biophysical research communications, Vol. 377, Issue 1, pp. 215-20, 2008 (PubMed).

Foley, van Vlijmen, Boynton, Adkins, Cheung, Singh, Sanicola, Young, Wen: "The CRIPTO/FRL-1/CRYPTIC (CFC) domain of human Cripto. Functional and structural insights through disulfide structure analysis." in: European journal of biochemistry / FEBS, Vol. 270, Issue 17, pp. 3610-8, 2003 (PubMed).

Bianco, Adkins, Wechselberger, Seno, Normanno, De Luca, Sun, Khan, Kenney, Ebert, Williams, Sanicola, Salomon: "Cripto-1 activates nodal- and ALK4-dependent and -independent signaling pathways in mammary epithelial Cells." in: Molecular and cellular biology, Vol. 22, Issue 8, pp. 2586-97, 2002 (PubMed).