产品详情
查看大图

  • 产品名称：SoluteCarrierFamily3(ActivatorsofDibasicandNeutralAminoAcidTransport),Member2(S

  • 产品型号：
  • 产品厂商：ACROBiosystems
  • 产品文档：
你添加了1件商品 查看购物车
简单介绍：
SoluteCarrierFamily3(ActivatorsofDibasicandNeutralAminoAcidTransport),Member2(SLC3A2)(AA206-630)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 47.7 kDa. The protein migrates as 50-75 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background CD antigen CD98 is also known as 4F2 cell-surface antigen heavy chain (4F2hc), 4F2 heavy chain antigen, Solute carrier family 3 member 2 (SLC3A2), Lymphocyte activation antigen 4F2 large subunit, is a single-pass type I I membrane protein which belongs to the SLC3A transporter family.. SLC3A2 / CD98 is expressed ubiquitously in all tissues tested with highest levels detected in kidney, placenta and testis and weakest level in thymus. SLC3A2 / CD98 is required for the function of light chain amino-acid transporters and also involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. CD98 involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A5 or SLC7A8, CD98 involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Together with ICAM1, regulates the transport activity LAT2 in polarized intestinal cells, by generating and delivering intracellular signals.
Molecular Weight 47.7 kDa
UniProt P08195
Research Area CD Antigens, Surface Receptors of Immune Cells
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Solute Carrier Family 3 (Activators of Dibasic and Neutral Amino Acid Transport), Member 2 (SLC3A2) (AA 206-630) (Active) protein (His tag) (ABIN2180859) Human CD98, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained ove...
Background publications Li, Whorton: "Identification of stereoselective transporters for S-nitroso-L-cysteine: role of LAT1 and LAT2 in biological activity of S-nitrosothiols." in: The Journal of biological chemistry, Vol. 280, Issue 20, pp. 20102-10, 2005 (PubMed).

Yanagida, Kanai, Chairoungdua, Kim, Segawa, Nii, Cha, Matsuo, Fukushima, Fukasawa, Tani, Taketani, Uchino, Kim, Inatomi, Okayasu, Miyamoto, Takeda, Goya, Endou: "Human L-type amino acid transporter 1 (LAT1): characterization of function and expression in tumor cell lines." in: Biochimica et biophysica acta, Vol. 1514, Issue 2, pp. 291-302, 2001 (PubMed).

Mastroberardino, Spindler, Pfeiffer, Skelly, Loffing, Shoemaker, Verrey: "Amino-acid transport by heterodimers of 4F2hc/CD98 and members of a permease family." in: Nature, Vol. 395, Issue 6699, pp. 288-91, 1998 (PubMed).