产品详情
  • 产品名称:TumorNecrosisFactorReceptorSuperfamily,Member4(TNFRSF4)(AA29-216)(Active)protei

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  • 产品厂商:ACROBiosystems
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简单介绍:
TumorNecrosisFactorReceptorSuperfamily,Member4(TNFRSF4)(AA29-216)(Active)protein(FcTag)
详情介绍:
Characteristics This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 46.8 kDa. The protein migrates as 65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >90 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
ProductDetails: Biological Activity Comment Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized rh TNFRSF4 / OX40 / CD134 Fc Chimera at 2 μg/mL (100 μL/well) can bind human TNFSF4, The EC50 of human TNFSF4 is 50 ng/mL.
Background Tumor necrosis factor receptor superfamily member 4 (TNFRSF4) is also known as ACT35 antigen, OX40L receptor, TAX transcriptionally-activated glycoprotein 1 receptor, CD antigen CD134, OX40. OX40 / TNFRSF4 contains four TNFR-Cys repeats. TNFRSF4 is receptor for TNFSF4 / OX40L / GP34 and can interacts with TRAF2, TRAF3 and TRAF5.
Molecular Weight 46.8 kDa
NCBI Accession NP_003318
UniProt P43489
Pathways Production of Molecular Mediator of Immune Response
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 50 mM Tris, 100 mM Glycine, pH 7.5
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) (AA 29-216) (Active) protein (Fc Tag) (ABIN2181573) Human OX40, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained over...
Binding Studies (Bind) image for Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) (AA 29-216) (Active) protein (Fc Tag) (ABIN2181573) Immobilized Human OX40 Ligand, His Tag (Cat# OXL-H52Q8) at 5 μg/mL (100 μl/well) can ...
Background publications Arch, Thompson: "4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB." in: Molecular and cellular biology, Vol. 18, Issue 1, pp. 558-65, 1998 (PubMed).

Kawamata, Hori, Imura, Takaori-Kondo, Uchiyama: "Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation." in: The Journal of biological chemistry, Vol. 273, Issue 10, pp. 5808-14, 1998 (PubMed).