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  • 产品名称：Interleukin17ReceptorA(IL17RA)(AA33-320)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
Interleukin17ReceptorA(IL17RA)(AA33-320)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 34.3 kDa. The protein migrates as 55-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >98 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
ProductDetails: Biological Activity Comment Biological Activity: Measured by its ability to inhibit IL-17 induced IL-6 secretion by NIH-3T3 mouse embryonic fibroblast cells. The ED50 for this effect is typically 0.01-0.1 μg/mL in the presence of 10 ng/mL recombinant human IL-17.
Background Interleukin 17 receptor A (IL17RA) is also known as cluster of differentiation w217 (CDw217), is a pro-inflammatory cytokine secreted by activated T-lymphocytes, belong to ubiquitous type I membrane glycoprotein, and binds with low affinity to interleukin 17A (IL17A). IL 17R mRNA exhibits a broad tissue distribution, and has been detected in virtually all cells and tissues tested . IL 17RA associates with IL 17RC to form a signaling receptor complex for IL 17 and IL 17F . Ligand and IL 17RA ligation promotes T cell activation and the production of IL - 6, G-CSF, SCF, and multiple pro-inflammatory chemokines. Defects in IL17RA are the cause of familial candidiasis type 5 (CANDF5).
Molecular Weight 34.3 kDa
NCBI Accession NP_055154
UniProt Q96F46
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
Supplier Images
SDS-PAGE (SDS) image for Interleukin 17 Receptor A (IL17RA) (AA 33-320) (Active) protein (His tag) (ABIN2181343) Interleukin 17 Receptor A (IL17RA) (AA 33-320) (Active) protein (His tag)
Background publications Puel, Cypowyj, Bustamante, Wright, Liu, Lim, Migaud, Israel, Chrabieh, Audry, Gumbleton, Toulon, Bodemer, El-Baghdadi, Whitters, Paradis, Brooks, Collins, Wolfman, Al-Muhsen, Galicchio, Abel, Picard et al.: "Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity. ..." in: Science (New York, N.Y.), Vol. 332, Issue 6025, pp. 65-8, 2011 (PubMed).

Ely, Fischer, Garcia: "Structural basis of receptor sharing by interleukin 17 cytokines." in: Nature immunology, Vol. 10, Issue 12, pp. 1245-51, 2009 (PubMed).