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  • 产品名称：FattyAcidBindingProtein2,Intestinal(FABP2)(AA2-132)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
FattyAcidBindingProtein2,Intestinal(FABP2)(AA2-132)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 16 kDa. The protein migrates as 16 kDa under reducing (R) condition (SDS-PAGE).
Purity >98 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
ProductDetails: Biological Activity Comment Biological Activity: The binding affinity of Recombinant Human FABP2/I-FABP for the synthetic ligand cis-parinaric acid has been measured by fluorescence titration. Half-maximal fluorescence of 3 μM Recombinant Human FABP2/I-FABP is achieved with approximately 3 μM cis-paranaric acid.
Background Fatty acid-binding protein 2 (FABP2), is also known as Fatty acid-binding protein, intestinal (FABPI), Intestinal-type fatty acid-binding protein (I-FABP). FABP2 belongs to the calycin superfamily and Fatty-acid binding protein (FABP) family. FABP2 / FABPI is expressed in the small intestine and at much lower levels in the large intestine and is highest expressed in the jejunum. FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. FABP2 binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor.
Molecular Weight 16 kDa
NCBI Accession NP_000125
UniProt P12104
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Fatty Acid Binding Protein 2, Intestinal (FABP2) (AA 2-132) (Active) protein (His tag) (ABIN2181053) Human FABP2, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained ov...
Background publications Sidawy, Perler: "A tribute to: Jack L. Cronenwett, MD, editor-in-chief James M. Seeger, MD, Senior Editor the Journal of Vascular Surgery January 1, 2003-December 31, 2008." in: Journal of vascular surgery, Vol. 49, Issue 1, pp. 1-2, 2009 (PubMed).

Pelsers, Namiot, Kisielewski, Namiot, Januszkiewicz, Hermens, Glatz: "Intestinal-type and liver-type fatty acid-binding protein in the intestine. Tissue distribution and clinical utility." in: Clinical biochemistry, Vol. 36, Issue 7, pp. 529-35, 2003 (PubMed).

Darimont, Gradoux, de Pover: "Epidermal growth factor regulates fatty acid uptake and metabolism in Caco-2 cells." in: The American journal of physiology, Vol. 276, Issue 3 Pt 1, pp. G606-12, 1999 (PubMed).