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  • 产品名称：ActivatedLeukocyteCellAdhesionMolecule(ALCAM)(AA28-526)(Active)protein(FcTag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
ActivatedLeukocyteCellAdhesionMolecule(ALCAM)(AA28-526)(Active)protein(FcTag)
详情介绍：
Characteristics This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 82.6 kDa. The protein migrates as 95-120 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background CD166 antigen is a 100-105 kD typeI transmembrane glycoprotein that is a member of the immunoglobulin superfamily of proteins, which is also known as Activated leukocyte cell adhesion molecule (ALCAM) in human, SC-1/DM-GRASP/BEN in the chicken, and KG-CAM in the rat. CD166 is a cell adhesion molecule that binds to CD6. CD166 involved in neurite extension by neurons via heterophilic and homophilic interactions.
Molecular Weight 82.6 kDa
NCBI Accession NP_001618
UniProt Q13740
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 50 mM Tris, 100 mM Glycine, pH 7.5
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Activated Leukocyte Cell Adhesion Molecule (ALCAM) (AA 28-526) (Active) protein (Fc Tag) (ABIN2180703) Human ALCAM, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained ove...
Background publications Skonier, Bowen, Emswiler, Aruffo, Bajorath: "Recognition of diverse proteins by members of the immunoglobulin superfamily: delineation of the receptor in the human CD6 ligand ALCAM." in: Biochemistry, Vol. 35, Issue 38, pp. 12287-91, 1996 (PubMed).

Bajorath, Bowen, Aruffo: "Molecular model of the N-terminal receptor-binding domain of the human CD6 ligand ALCAM." in: Protein science : a publication of the Protein Society, Vol. 4, Issue 8, pp. 1644-7, 1996 (PubMed).