产品详情
查看大图

  • 产品名称：FcFragmentofIgG,LowAffinityIIb,Receptor(CD32)(FCGR2B)(AA46-217)(Active)protein(

  • 产品型号：
  • 产品厂商：ACROBiosystems
  • 产品文档：
你添加了1件商品 查看购物车
简单介绍：
FcFragmentofIgG,LowAffinityIIb,Receptor(CD32)(FCGR2B)(AA46-217)(Active)protein(Histag)
详情介绍：
Brand MABSol®
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 20.4 kDa. The protein migrates as 23-33 kDa under reducing (R) condition (SDS-PAGE) due to different glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
ProductDetails: Biological Activity Comment Biological Activity: Measured by its ability to bind human IgG with an estimated KD <150 nm.="" <="" td="">
Background Receptors for the Fc region of IgG (Fc γ R) are members of the Ig superfamily that function in the activation or inhibition of immune responses. Three classes of human Fc γ Rs: RI (CD64), RII (CD32), and RIII (CD16), which generate multiple isoforms, are recognized. There are three genes for human Fcγ RII /CD32 (A, B, and C) and one for mouse Fcγ RII B (CD32B). CD32 is a low affinity receptor for IgG. Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B) is also known as CD32b, FCG2, IGFR2. CD32B is expressed on B cells and myeloid dendritic cells. Ligation of CD32B on B cells downregulates antibody production and may, in some circumstances, promote apoptosis. Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation. CD32B may also be a target for monoclonal antibody therapy for malignancies.
Molecular Weight 20.4 kDa
NCBI Accession NP_001002273
UniProt P31994
Pathways Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
Supplier Images
SDS-PAGE (SDS) image for Fc Fragment of IgG, Low Affinity IIb, Receptor (CD32) (FCGR2B) (AA 46-217) (Active) protein (His tag) (ABIN2180754) Fc Fragment of IgG, Low Affinity IIb, Receptor (CD32) (FCGR2B) (AA 46-217) (Active) protein (His tag)
Background publications Laine, Bourhis, Longhi, Flacher, Cassard, Canard, Sautès-Fridman, Rabourdin-Combe, Valentin: "Measles virus nucleoprotein induces cell-proliferation arrest and apoptosis through NTAIL-NR and NCORE-FcgammaRIIB1 interactions, respectively." in: The Journal of general virology, Vol. 86, Issue Pt 6, pp. 1771-84, 2005 (PubMed).

Sarmay, Koncz, Pecht, Gergely: "Fc gamma receptor type IIb induced recruitment of inositol and protein phosphatases to the signal transductory complex of human B-cell." in: Immunology letters, Vol. 57, Issue 1-3, pp. 159-64, 1997 (PubMed).

Hamada, Aoki, Akiyama, Toyoshima: "Association of immunoglobulin G Fc receptor II with Src-like protein-tyrosine kinase Fgr in neutrophils." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, Issue 13, pp. 6305-9, 1993 (PubMed).