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  • 产品名称：Interferonalpha/betaReceptor2(IFNAR2)(AA27-243)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
Interferonalpha/betaReceptor2(IFNAR2)(AA27-243)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 25.6 kDa. The protein migrates as 40-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Interferon alpha/beta receptor 2 (IFNAR2) is also known as IFN-alpha binding protein, IFN-alpha/beta receptor 2, Type I interferon receptor 2, IFNABR and IFNARB, which is a single-pass type I membrane protein and belongs to the type II cytokine receptor family. IFNAR2 can associate with IFNAR1 to form the type I interferon receptor. IFNAR2 is a receptor for interferons alpha and beta.IFNAR2 involves in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 of IFNAR2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 of IFNAR2 is a potent inhibitor of type I IFN receptor activity.Genetic variations in IFNAR2 influence susceptibility to hepatitis B virus (HBV) infection.
Molecular Weight 25.6 kDa
NCBI Accession NP_997467
UniProt P48551
Pathways JAK-STAT Signaling, Hepatitis C
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Interferon alpha/beta Receptor 2 (IFNAR2) (AA 27-243) (Active) protein (His tag) (ABIN2181252) Human IFN-alpha/beta R2, His Tag on SDS-PAGE under reducing (R) condition. The gel wa...
Background publications Li, Leung, Kerr, Stark: "Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling." in: Molecular and cellular biology, Vol. 17, Issue 4, pp. 2048-56, 1997 (PubMed).

Novick, Cohen, Tal, Rubinstein: "Soluble and membrane-anchored forms of the human IFN-alpha/beta receptor." in: Journal of leukocyte biology, Vol. 57, Issue 5, pp. 712-8, 1995 (PubMed).

Novick, Cohen, Rubinstein: "The human interferon alpha/beta receptor: characterization and molecular cloning." in: Cell, Vol. 77, Issue 3, pp. 391-400, 1994 (PubMed).