产品详情
查看大图

  • 产品名称：Azurocidin1(AZU1)(AA27-250)(Active)protein(Histag)

  • 产品型号：
  • 产品厂商：ACROBiosystems
  • 产品文档：
你添加了1件商品 查看购物车
简单介绍：
Azurocidin1(AZU1)(AA27-250)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 25 kDa. The protein migrates as 32-40 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Azurocidin (AZU1) is also known as Heparin-binding protein (HBP), Cationic antimicrobial protein CAP37, is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. which belongs to the peptidase S1 family and elastase subfamily. AZU1 / HBP contains 1 peptidase S1 domain. AZU1 binds heparin. The cytotoxic action of AZU1 is limited to many species of Gram-negative bacteria, this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. AZU1 may play a role in mediating recruitment of monocytes in the second wave of inflammation.
Molecular Weight 25 kDa
UniProt P20160
Research Area Atherosclerosis, Innate Immunity
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Azurocidin 1 (AZU1) (AA 27-250) (Active) protein (His tag) (ABIN2180608) Human Azurocidin, His Tag on SDS-PAGE under reducing (R) condition. The gel was stain...
Background publications Lala, Lindemann, Miyasaki: "The differential effects of polymorphonuclear leukocyte secretion on human natural killer cell activity." in: Oral microbiology and immunology, Vol. 7, Issue 2, pp. 89-95, 1992 (PubMed).

Miyasaki, Bodeau: "Human neutrophil azurocidin synergizes with leukocyte elastase and cathepsin G in the killing of Capnocytophaga sputigena." in: Infection and immunity, Vol. 60, Issue 11, pp. 4973-5, 1992 (PubMed).

Wasiluk, Skubitz, Gray: "Comparison of granule proteins from human polymorphonuclear leukocytes which are bactericidal toward Pseudomonas aeruginosa." in: Infection and immunity, Vol. 59, Issue 11, pp. 4193-200, 1991 (PubMed).