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  • 产品名称：V-SetandImmunoglobulinDomain-ContainingProtein4(VSIG4)(AA20-283)(Active)protein

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  • 产品厂商：ACROBiosystems
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简单介绍：
V-SetandImmunoglobulinDomain-ContainingProtein4(VSIG4)(AA20-283)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 30 kDa. The protein migrates as 45-48 kDa under reducing (R) condition (SDS-PAGE).
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background V-set and immunoglobulin domain-containing protein 4 (VSIG4) is also known as Protein Z39Ig, is a type I transmembrane glycoprotein. VSIG4 is a B7 family-related protein and an Ig superfamily member. VSIG4 contains two Ig-like (immunoglobulin-like) domains. VSIG4 is abundantly expressed in several fetal tissues. In ***** tissues, the highest expression of VSIG4 is in lung and placenta. VSIG4 functions as a negative regulator of T cell activation, and may be involved in the maintenance of peripheral T cell tolerance, and is also identified as a potent suppressor of established inflammation. VSIG4 is a phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production.
Molecular Weight 30 kDa
UniProt Q9Y279
Research Area Immunology, Innate Immunity
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for V-Set and Immunoglobulin Domain-Containing Protein 4 (VSIG4) (AA 20-283) (Active) protein (His tag) (ABIN2181925) Human VSIG4, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained ov...
Background publications Wiesmann, Katschke, Yin, Helmy, Steffek, Fairbrother, McCallum, Embuscado, DeForge, Hass, van Lookeren Campagne: "Structure of C3b in complex with CRIg gives insights into regulation of complement activation." in: Nature, Vol. 444, Issue 7116, pp. 217-20, 2006 (PubMed).

Vogt, Schmitz, Kurrer, Bauer, Hinton, Behnke, Gatto, Sebbel, Beerli, Sonderegger, Kopf, Saudan, Bachmann: "VSIG4, a B7 family-related protein, is a negative regulator of T cell activation." in: The Journal of clinical investigation, Vol. 116, Issue 10, pp. 2817-26, 2006 (PubMed).