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  • 产品名称：SLAMFamilyMember7(SLAMF7)(AA23-226)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
SLAMFamilyMember7(SLAMF7)(AA23-226)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 23.2 kDa. The protein migrates as 33-48 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
ProductDetails: Biological Activity Comment Biological Activity: Measured by its ability to bind biotinylated human SLAMF7 in a functional ELISA.
Background SLAM family member 7 (SLAMF7) is also known as CD2-like receptor-activating cytotoxic cells (CRACC), Membrane protein FOAP-12, CD antigen CD319, Novel Ly9, Protein 19A, which is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. SLAMF7 is expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung and trachea. Isoform 1 of SLAMF7 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway. May play a role in lymphocyte adhesion. Isoform 3 of SLAMF7 does not mediate any NK cell activation.
Molecular Weight 23.2 kDa
UniProt Q9NQ25
Research Area Immunology, Innate Immunity
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for SLAM Family Member 7 (SLAMF7) (AA 23-226) (Active) protein (His tag) (ABIN2181775) Human SLAMF7, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained o...
Background publications Murphy, Hobby, Vilarino-Varela, Bishop, Iordanidou, Sutton, Norton: "A novel immunoglobulin superfamily receptor (19A) related to CD2 is expressed on activated lymphocytes and promotes homotypic B-cell adhesion." in: The Biochemical journal, Vol. 361, Issue Pt 3, pp. 431-6, 2002 (PubMed).

Bouchon, Cella, Grierson, Cohen, Colonna: "Activation of NK cell-mediated cytotoxicity by a SAP-independent receptor of the CD2 family." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 10, pp. 5517-21, 2001 (PubMed).