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  • 产品名称：FattyAcidBindingProtein3,MuscleandHeart(FABP3)(AA1-133)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
FattyAcidBindingProtein3,MuscleandHeart(FABP3)(AA1-133)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 15.7 kDa. The protein migrates as 16 kDa under reducing (R) condition (SDS-PAGE).
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Fatty acid-binding protein 3 (FABP3) is also known as Heart-type fatty acid binding protein (H-FABP), Mammary-derived growth inhibitor (MDGI), Muscle fatty acid-binding protein (M-FABP), FABP11, which belongs to the calycin superfamily and fatty-acid binding protein (FABP) family. FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. H-FABP / FABP3 is involved in active fatty acid metabolism where it transports fatty acids from the cell membrane to mitochondria for oxidation. FABP3 may also contribute to AS160 phosphorylation by maintaining insulin-dependent Akt activation in the cells under a lipotoxic condition.
Molecular Weight 15.7 kDa
NCBI Accession NP_004093
UniProt P05413
Pathways Monocarboxylic Acid Catabolic Process
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Fatty Acid Binding Protein 3, Muscle and Heart (FABP3) (AA 1-133) (Active) protein (His tag) (ABIN2181054) Human FABP3, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained ov...
Background publications Kleine, Glatz, Van Nieuwenhoven, Van der Vusse: "Release of heart fatty acid-binding protein into plasma after acute myocardial infarction in man." in: Molecular and cellular biochemistry, Vol. 116, Issue 1-2, pp. 155-62, 1993 (PubMed).

Börchers, Højrup, Nielsen, Roepstorff, Spener, Knudsen: "Revision of the amino acid sequence of human heart fatty acid-binding protein." in: Molecular and cellular biochemistry, Vol. 98, Issue 1-2, pp. 127-33, 1991 (PubMed).

Offner, Brecher, Sawlivich, Costello, Troxler: "Characterization and amino acid sequence of a fatty acid-binding protein from human heart." in: The Biochemical journal, Vol. 252, Issue 1, pp. 191-8, 1988 (PubMed).