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  • 产品名称：DiscoidinDomainReceptortyrosineKinase2(DDR2)(AA22-399)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
DiscoidinDomainReceptortyrosineKinase2(DDR2)(AA22-399)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 44.6 kDa. The protein migrates as 50-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by reduced SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Discoidin domain-containing receptor 2 (DDR2) is also known as CD167 antigen-like family member B (CD167b), Discoidin domain-containing receptor tyrosine kinase 2, Neurotrophic tyrosine kinase, receptor-related 3(NTRKR3), Tyrosine-protein kinase TYRO10, Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. DDR2 is required for normal bone development. DDR2 regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. DDR2 regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. DDR2 promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.
Molecular Weight 44.6 kDa
UniProt F7HJQ2
Research Area Cardiovascular, Cardiogenesis
Pathways RTK Signaling
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Discoidin Domain Receptor tyrosine Kinase 2 (DDR2) (AA 22-399) (Active) protein (His tag) (ABIN2180959) Rhesus macaque DDR2, His Tag on SDS-PAGE under reducing (R) condition. The gel was st...
Background publications Konitsiotis, Raynal, Bihan, Hohenester, Farndale, Leitinger: "Characterization of high affinity binding motifs for the discoidin domain receptor DDR2 in collagen." in: The Journal of biological chemistry, Vol. 283, Issue 11, pp. 6861-8, 2008 (PubMed).

Gibbs, Rogers, Katze, Bumgarner, Weinstock, Mardis, Remington, Strausberg, Venter, Wilson, Batzer, Bustamante, Eichler, Hahn, Hardison, Makova, Miller, Milosavljevic, Palermo, Siepel, Sikela, Attaway et al.: "Evolutionary and biomedical insights from the rhesus macaque genome. ..." in: Science (New York, N.Y.), Vol. 316, Issue 5822, pp. 222-34, 2007 (PubMed).

Xu, Peng, Glasson, Lee, Hu, Ijiri, Olsen, Goldring, Li: "Increased expression of the collagen receptor discoidin domain receptor 2 in articular cartilage as a key event in the pathogenesis of osteoarthritis." in: Arthritis and rheumatism, Vol. 56, Issue 8, pp. 2663-73, 2007 (PubMed).