产品详情
查看大图

  • 产品名称：CellAdhesionMolecule3(CADM3)(AA25-330)(Active)protein(Histag)

  • 产品型号：
  • 产品厂商：ACROBiosystems
  • 产品文档：
你添加了1件商品 查看购物车
简单介绍：
CellAdhesionMolecule3(CADM3)(AA25-330)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 34.5 kDa. The protein migrates as 38-42 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >90 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Cell adhesion molecule 3 (CADM3) is also known as Synaptic cell adhesion molecule 3 (SynCAM3), Immunoglobulin superfamily member 4B (IgSF4B), Brain immunoglobulin receptor (BIgR), Nectin-like protein 1 (NECL-1), TSLC1-like protein 1 (TSLL1), which belongs to the nectin family. CADM3 contains two Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain.The isoform 1 is expressed mainly in ***** and fetal brain and isoform 2 is highly expressed in ***** brain and weakly expressed in placenta. In brain, Isoform 2 is highly expressed in cerebellum. CADM3 involved in the cell-cell adhesion and has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, PVRL1 and PVRL3. CADM3 / SynCAM3 interaction with EPB41L1 may regulate structure or function of cell-cell junctions.
Molecular Weight 34.5 kDa
UniProt Q8N126
Research Area Neurology
Pathways Cell-Cell Junction Organization
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
Supplier Images
SDS-PAGE (SDS) image for Cell Adhesion Molecule 3 (CADM3) (AA 25-330) (Active) protein (His tag) (ABIN2181288) Human CADM3, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained ov...
Background publications Dong, Xu, Gong, Gao, Lin, Chen, Peng, Qiang, Yuan, Peng, Rao: "Crystal structure of the V domain of human Nectin-like molecule-1/Syncam3/Tsll1/Igsf4b, a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule." in: The Journal of biological chemistry, Vol. 281, Issue 15, pp. 10610-7, 2006 (PubMed).

Fukuhara, Kuramochi, Nobukuni, Fukami, Saino, Maruyama, Nomura, Sekiya, Murakami: "Isolation of the TSLL1 and TSLL2 genes, members of the tumor suppressor TSLC1 gene family encoding transmembrane proteins." in: Oncogene, Vol. 20, Issue 38, pp. 5401-7, 2001 (PubMed).