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  • 产品名称：SecretedandTransmembrane1(SECTM1)(AA29-145)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
SecretedandTransmembrane1(SECTM1)(AA29-145)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 13.5 kDa. The protein migrates as 18-23 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >92 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Secreted and transmembrane protein 1 (SECTM1) is also known as Protein K-12, which is belongs to the SECTM family, which is Inducted by IFNG/IFN-gamma (at protein level). SECTM1 is detected at the highest levels in peripheral blood leukocytes and breast cancer cell lines. SECTM1 may be involved in thymocyte signaling.
Molecular Weight 13.5 kDa
UniProt Q8WVN6
Research Area Cancer
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Secreted and Transmembrane 1 (SECTM1) (AA 29-145) (Active) protein (His tag) (ABIN2181733) Human SECTM1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained o...
Background publications Ouyang, Garnett, Han, Hama, Lee, Deng, Lee, Liu, Amacher, Farber, Ho: "A web based resource characterizing the zebrafish developmental profile of over 16,000 transcripts." in: Gene expression patterns : GEP, Vol. 8, Issue 3, pp. 171-80, 2008 (PubMed).

Lam, Liao, Xue, Alam, Scearce, Kaufman, Sempowski, Haynes: "Expression of the CD7 ligand K-12 in human thymic epithelial cells: regulation by IFN-gamma." in: Journal of clinical immunology, Vol. 25, Issue 1, pp. 41-9, 2005 (PubMed).

McKenna, Stocking, Miller, Brasel, De Smedt, Maraskovsky, Maliszewski, Lynch, Smith, Pulendran, Roux, Teepe, Lyman, Peschon: "Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells." in: Blood, Vol. 95, Issue 11, pp. 3489-97, 2000 (PubMed).

Lyman, Escobar, Rousseau, Armstrong, Fanslow: "Identification of CD7 as a cognate of the human K12 (SECTM1) protein." in: The Journal of biological chemistry, Vol. 275, Issue 5, pp. 3431-7, 2000 (PubMed).

Slentz-Kesler, Hale, Kaufman: "Identification and characterization of K12 (SECTM1), a novel human gene that encodes a Golgi-associated protein with transmembrane and secreted isoforms." in: Genomics, Vol. 47, Issue 3, pp. 327-40, 1998 (PubMed).