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  • 产品名称：AXLReceptortyrosineKinase(AXL)(AA26-449)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
AXLReceptortyrosineKinase(AXL)(AA26-449)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 46.6 kDa. The protein migrates as 60-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >92 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background AXL Receptor Tyrosine Kinase is also known as Tyrosine-protein kinase receptor UFO, which belongs to the protein kinase superfamily, Tyr protein kinase family and AXL/UFO subfamily. AXL contains two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains and one protein kinase domain. AXL is highly expressed in metastatic colon tumors. AXL is activated by GAS6-binding and subsequent autophosphorylation. AXL is involved in signal transduction from the extracellular matrix into the cytoplasm by binding growth factors, and thus implicated in the stimulation of cell proliferation.
Molecular Weight 46.6 kDa
UniProt P30530
Research Area Cancer, Cell Cycle, Tyrosine Kinases, Kinases/Phosphatases
Pathways RTK Signaling, Cellular Response to Molecule of Bacterial Origin
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for AXL Receptor tyrosine Kinase (AXL) (AA 26-449) (Active) protein (His tag) (ABIN2180607) Human Axl, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained over...
Background publications Park, Giovenzana, Hughes, Yu, Trotta, Caligiuri: "The Axl/Gas6 pathway is required for optimal cytokine signaling during human natural killer cell development." in: Blood, Vol. 113, Issue 11, pp. 2470-7, 2009 (PubMed).

Gallicchio, Mitola, Valdembri, Fantozzi, Varnum, Avanzi, Bussolino: "Inhibition of vascular endothelial growth factor receptor 2-mediated endothelial cell activation by Axl tyrosine kinase receptor." in: Blood, Vol. 105, Issue 5, pp. 1970-6, 2005 (PubMed).

Toombs, Young, Glaspy, Varnum: "Megakaryocyte growth and development factor (MGDF) moderately enhances in-vitro platelet aggregation." in: Thrombosis research, Vol. 80, Issue 1, pp. 23-33, 1996 (PubMed).

Varnum, Young, Elliott, Garcia, Bartley, Fridell, Hunt, Trail, Clogston, Toso: "Axl receptor tyrosine kinase stimulated by the vitamin K-dependent protein encoded by growth-arrest-specific gene 6." in: Nature, Vol. 373, Issue 6515, pp. 623-6, 1995 (PubMed).