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  • 产品名称:CD44(CD44)(AA21-220)(Active)protein(FcTag)

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  • 产品厂商:ACROBiosystems
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简单介绍:
CD44(CD44)(AA21-220)(Active)protein(FcTag)
详情介绍:
Characteristics This protein carries a human IgG1 Fc tag at the C-terminus, and has a calculated MW of 48.7 kDa. The predicted N-terminus is Gln 21. The reducing (R) protein migrates as 76 kDa in SDS-PAGE due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background CD44 antigen is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. CD44 is expressed in a large number of mammalian cell types. CD44 is a receptor for hyaluronic acid and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). CD44 function is controlled by its posttranslational modifications. One critical modification involves discrete sialofucosylations rendering the selectin-binding glycoform of CD44 called HCELL (for Hematopoietic Cell E-selectin/L-selectin Ligand). CD44 participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms.
Molecular Weight 48.7 kDa
UniProt P16070
Research Area Stem Cells, Hematopoietic Progenitors, CD Antigens, Surface Receptors of Immune Cells, Cancer, Cell Cycle
Pathways Glycosaminoglycan Metabolic Process, Autophagy, Negative Regulation of intrinsic apoptotic Signaling
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 50 mM Tris, 100 mM Glycine, pH 7.5
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for CD44 (CD44) (AA 21-220) (Active) protein (Fc Tag) (ABIN2180800) Human CD44, Fc Tag (HPLC-verified) on SDS-PAGE under reducing (R) condition. The gel ...
Background publications Hanley, Burdick, Konstantopoulos, Sackstein: "CD44 on LS174T colon carcinoma cells possesses E-selectin ligand activity." in: Cancer research, Vol. 65, Issue 13, pp. 5812-7, 2005 (PubMed).