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  • 产品名称：VAMP(Vesicle-AssociatedMembraneProtein)-AssociatedProteinBandC(VAPB)(AA1-138)(A

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  • 产品厂商：ACROBiosystems
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简单介绍：
VAMP(Vesicle-AssociatedMembraneProtein)-AssociatedProteinBandC(VAPB)(AA1-138)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 15.8 kDa. The protein migrates as 16-18 kDa under reducing (R) condition (SDS-PAGE).
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Vesicle-associated membrane protein-associated protein B/C (VAPB) is also known as VAMP-associated protein B/C (VAMP-B/VAMP-C or VAP-B/VAP-C), which is a single-pass type IV membrane protein and belongs to the VAMP-associated protein ( VAP ) family. Involved in cellular calcium homeostasis regulation, VAPB participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity as well. VAPB can interact with VAMP1 ,VAMP2, HCV NS5A, NS5B ,ZFYVE27 (via MSP domain) and RMDN3. Human VAPB is involved in hepatitis C virus replication through interaction with NS5A and NS5B.
Molecular Weight 15.8 kDa
NCBI Accession NP_004729
UniProt O95292
Pathways ER-Nucleus Signaling
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for VAMP (Vesicle-Associated Membrane Protein)-Associated Protein B and C (VAPB) (AA 1-138) (Active) protein (His tag) (ABIN2181890) Human VAP-B, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained ov...
Background publications Saita, Shirane, Natume, Iemura, Nakayama: "Promotion of neurite extension by protrudin requires its interaction with vesicle-associated membrane protein-associated protein." in: The Journal of biological chemistry, Vol. 284, Issue 20, pp. 13766-77, 2009 (PubMed).

Fujimoto, Hamamoto, Taniguchi, Chikahira, Okabe: "Molecular epidemiology of adenovirus type 3 detected from 1994 to 2006 in Hyogo Prefecture, Japan." in: Japanese journal of infectious diseases, Vol. 61, Issue 2, pp. 143-5, 2008 (PubMed).

Kanekura, Nishimoto, Aiso, Matsuoka: "Characterization of amyotrophic lateral sclerosis-linked P56S mutation of vesicle-associated membrane protein-associated protein B (VAPB/ALS8)." in: The Journal of biological chemistry, Vol. 281, Issue 40, pp. 30223-33, 2006 (PubMed).

Hamamoto, Nishimura, Okamoto, Aizaki, Liu, Mori, Abe, Suzuki, Lai, Miyamura, Moriishi, Matsuura: "Human VAP-B is involved in hepatitis C virus replication through interaction with NS5A and NS5B." in: Journal of virology, Vol. 79, Issue 21, pp. 13473-82, 2005 (PubMed).