产品详情
  • 产品名称:SMT3SuppressorofMifTwo3Homolog1(S.Cerevisiae)(SUMO1)(AA1-101)(Active)protein(Hi

  • 产品型号:
  • 产品厂商:ACROBiosystems
  • 产品文档:
你添加了1件商品 查看购物车
简单介绍:
SMT3SuppressorofMifTwo3Homolog1(S.Cerevisiae)(SUMO1)(AA1-101)(Active)protein(Histag)
详情介绍:
Characteristics This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 12.4 kDa. The protein migrates as 20 kDa under reducing (R) condition (SDS-PAGE).
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Small ubiquitin-related modifier 1 (SUMO1),a member of the ubiquitin family and SUMO subfamily, is also known as GAP-modifying protein 1 (GMP1), SMT3 homolog 3, ubiquitin-homology domain protein PIC1 and ubiquitin-like protein UBL1,which contains one ubiquitin-like domain. Cleavage of precursor form by SENP1 or SENP2 is necessary for the function of SUMO1. Polymeric SUMO1 chains undergo polyubiquitination by RNF4. SUMO1 may also regulate a network of genes involved in palate development.SUMO1 plays an important role in modulation of NOX activity required for ROS generation.
Molecular Weight 12.4 kDa
UniProt P63165
Research Area Signaling, Proteases, DNA/RNA
Pathways M Phase, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 50 mM Tris, 150 mM NaCl, pH 8.0
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for SMT3 Suppressor of Mif Two 3 Homolog 1 (S. Cerevisiae) (SUMO1) (AA 1-101) (Active) protein (His tag) (ABIN2181798) Human SUMO1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained ov...
Background publications Alkuraya, Saadi, Lund, Turbe-Doan, Morton, Maas: "SUMO1 haploinsufficiency leads to cleft lip and palate." in: Science (New York, N.Y.), Vol. 313, Issue 5794, pp. 1751, 2006 (PubMed).

Shen, Pardington-Purtymun, Comeaux, Moyzis, Chen: "UBL1, a human ubiquitin-like protein associating with human RAD51/RAD52 proteins." in: Genomics, Vol. 36, Issue 2, pp. 271-9, 1997 (PubMed).

Mahajan, Delphin, Guan, Gerace, Melchior: "A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2." in: Cell, Vol. 88, Issue 1, pp. 97-107, 1997 (PubMed).