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  • 产品名称：Insulin-LikeGrowthFactor2MRNABindingProtein2(IGF2BP2)(AA1-599)(Active)protein(H

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  • 产品厂商：ACROBiosystems
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简单介绍：
Insulin-LikeGrowthFactor2MRNABindingProtein2(IGF2BP2)(AA1-599)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 66.9 kDa. The protein migrates as 67 kDa on a SDS-PAGE gel under reducing (R) condition.
Purity >90 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Insulin-like growth factor 2 mRNA-binding protein 2 is also known as IGF2 mRNA-binding protein 2, Hepatocellular carcinoma autoantigen p62, IGF-II mRNA-binding protein 2, VICKZ family member 2, IGF2BP2 and IMP2, is a cytoplasm protein which belongs to the RRM IMP/VICKZ family. IGF2BP2 is expressed in oocytes, granulosa cells of small and growing follicles, Leydig cells, spermatogonia and semen (at protein level). Expressed in testicular cancer (at protein level). Expressed weakly in heart, placenta, skeletal muscle, bone marrow, colon, kidney, salivary glands, testis and pancreas. Detected in fetal liver, fetal ovary, gonocytes and interstitial cells of the testis.It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. IGF2BP2 / IMP2 may regulate translation of target mRNAs. Genetic variation at the IGF2BP2 gene has been associated with type 2 diabetes (T2D) by genome-wide association studies and by replication analyses.
Molecular Weight 66.9 kDa
NCBI Accession NP_006539
UniProt Q9Y6M1
Research Area Chromatin and Nuclear Signaling, Chromatin Binding Proteins, DNA/RNA
Restrictions For Research Use only
Format Lyophilized
Reconstitution For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 50 mM Tris-HCI, 10 mM reduced Glutathione, pH 8.0
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
Supplier Images
SDS-PAGE (SDS) image for Insulin-Like Growth Factor 2 MRNA Binding Protein 2 (IGF2BP2) (AA 1-599) (Active) protein (His tag) (ABIN2181267) Human IGF2BP2, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained ...
Background publications Zhang, Chan, Peng, Tan: "A novel cytoplasmic protein with RNA-binding motifs is an autoantigen in human hepatocellular carcinoma." in: The Journal of experimental medicine, Vol. 189, Issue 7, pp. 1101-10, 1999 (PubMed).