产品详情
查看大图

  • 产品名称：Myocilin(MYOC)(AA33-504)(Active)protein(Histag)

  • 产品型号：
  • 产品厂商：ACROBiosystems
  • 产品文档：
你添加了1件商品 查看购物车
简单介绍：
Myocilin(MYOC)(AA33-504)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 32 kDa. The protein migrates as 33 kDa under reducing (R) condition (SDS-PAGE) due to most of the MYOC was cleaved at Glu 214, generating a C-terminal fragment.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Myocilin, trabecular meshwork inducible glucocorticoid response is also known as MYOC, GLC1A, GPOA, JOAG, JOAG1, TIGR. Myocilin / MYOC contains one olfactomedin-like domain. Myocilin is believed to have a role in cytoskeletal function. MYOC is expressed in many occular tissues, including the trabecular meshwork, and was revealed to be the trabecular meshwork glucocorticoid-inducible response protein (TIGR). The trabecular meshwork is a specialized eye tissue essential in regulating intraocular pressure, and mutations in MYOC have been identified as the cause of hereditary juvenile-onset open-angle glaucoma.
Molecular Weight 32 kDa
NCBI Accession NP_000252
UniProt Q99972
Research Area Chromatin and Nuclear Signaling, Chromatin Binding Proteins
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Myocilin (MYOC) (AA 33-504) (Active) protein (His tag) (ABIN2181527) Human Myocilin, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained...
Background publications Kwon, Fingert, Kuehn, Alward: "Primary open-angle glaucoma." in: The New England journal of medicine, Vol. 360, Issue 11, pp. 1113-24, 2009 (PubMed).