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  • 产品名称：Decorin(DCN)(AA17-359)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
Decorin(DCN)(AA17-359)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 38.8 kDa. The protein migrates as 45 kDa or higher under reducing (R) condition (SDS-PAGE) due to different glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
ProductDetails: Biological Activity Comment Biological Activity: Measured by its ability to modulate collagen fibrillogenesis. At 5 μg/mL, rhDecorin can significantly delay the rate of type I collagen fibrillogenesis.
Background Decorin is also known as bone proteoglycan II, PGS2, SLRR1B, DCN, DSPG2 and PG40, is a secreted chondroitin /dermatan sulfate proteoglycan in the family of small leucine-rich proteoglycans (SLRPs). Decorin is a small cellular or pericellular matrix proteoglycan and is closely related in structure to biglycan protein. Decorin and biglycan are thought to be the result of a gene duplication. This protein is a component of connective tissue, binds to type I collagen fibrils, and plays a role in matrix assembly. Decorin appears to influence fibrillogenesis, and also interacts with fibronectin, thrombospondin, the complement component C1q, epidermal growth factor receptor (EGFR) and transforming growth factor-beta (TGF-beta). Defects in DCN are the cause of congenital stromal corneal dystrophy (CSCD).
Molecular Weight 38.8 kDa
NCBI Accession NP_001911
UniProt P07585
Research Area Stem Cells, Extracellular Matrix
Pathways Glycosaminoglycan Metabolic Process
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
Supplier Images
SDS-PAGE (SDS) image for Decorin (DCN) (AA 17-359) (Active) protein (His tag) (ABIN2180962) Human Decorin, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained ...
Background publications Santra, Reed, Iozzo: "Decorin binds to a narrow region of the epidermal growth factor (EGF) receptor, partially overlapping but distinct from the EGF-binding epitope." in: The Journal of biological chemistry, Vol. 277, Issue 38, pp. 35671-81, 2002 (PubMed).