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  • 产品名称：Lumican(LUM)(AA19-338)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
Lumican(LUM)(AA19-338)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 37.5 kDa. The protein migrates as 50-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by reduced SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Lumican (LUM) is also known as Keratan sulfate proteoglycan lumican, KSPG lumican,LDC and SLRR2D, which belongs to the small leucine-rich proteoglycan (SLRP) family and SLRP class II subfamily. LUM /Lumican is present in the extracellular matrix of human articular cartilage at all ages, although its abundance is far greater in the *****. In the ***** cartilage LUM /Lumican exists predominantly in a glycoprotein form lacking keratan sulfate, whereas the juvenile form of the molecule is a proteoglycan. LUM participates in the maintenance of tissue homeostasis and modulates cellular functions including cell proliferation, migration, and differentiation. The expression of LUM has been correlated to the growth and metastasis of various malignancies.
Molecular Weight 37.5 kDa
NCBI Accession NP_002336
UniProt P51884
Research Area Signaling, Extracellular Matrix
Pathways Glycosaminoglycan Metabolic Process
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Lumican (LUM) (AA 19-338) (Active) protein (His tag) (ABIN2181488) Human Lumican, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained ...
Background publications Onnerfjord, Heathfield, Heinegård: "Identification of tyrosine sulfation in extracellular leucine-rich repeat proteins using mass spectrometry." in: The Journal of biological chemistry, Vol. 279, Issue 1, pp. 26-33, 2003 (PubMed).

Grover, Chen, Korenberg, Roughley: "The human lumican gene. Organization, chromosomal location, and expression in articular cartilage." in: The Journal of biological chemistry, Vol. 270, Issue 37, pp. 21942-9, 1995 (PubMed).