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  • 产品名称：KillerCellImmunoglobulin-LikeReceptor,TwoDomains,LongCytoplasmicTail,3(KIR2DL3)

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  • 产品厂商：ACROBiosystems
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简单介绍：
KillerCellImmunoglobulin-LikeReceptor,TwoDomains,LongCytoplasmicTail,3(KIR2DL3)(AA22-245)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 25.4 kDa. The protein migrates as 45-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Killer cell immunoglobulin-like receptor 2DL3 (KIR2DL3) is also known as CD158 antigen-like family member B2, KIR-023GB, Killer inhibitory receptor cl 2-3, MHC class I NK cell receptor, NKAT2a, NKAT2b, Natural killer-associated transcript 2, p58 natural killer cell receptor clone CL-6, p58.2 MHC class-I-specific NK receptor, CD158b2 and KIR2DL3, which is a single-pass type I membrane protein and belongs to the immunoglobulin superfamily.KIR2DL3 is a receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). KIR2DL3 can inhibit the activity of NK cells thus preventing cell lysis.
Molecular Weight 25.4 kDa
NCBI Accession NP_056952
UniProt P43628
Research Area Immunology
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 3 (KIR2DL3) (AA 22-245) (Active) protein (His tag) (ABIN2181421) Human KIR2DL3, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained ...
Background publications Maenaka, Juji, Stuart, Jones: "Crystal structure of the human p58 killer cell inhibitory receptor (KIR2DL3) specific for HLA-Cw3-related MHC class I." in: Structure (London, England : 1993), Vol. 7, Issue 4, pp. 391-8, 1999 (PubMed).

Döhring, Samaridis, Colonna: "Alternatively spliced forms of human killer inhibitory receptors." in: Immunogenetics, Vol. 44, Issue 3, pp. 227-30, 1996 (PubMed).

Doehring, Sanda, Partin, Sauvageot, Juo, Beaty, Epstein, Hill, Walsh: "Histopathologic characterization of hereditary benign prostatic hyperplasia." in: Urology, Vol. 48, Issue 4, pp. 650-3, 1996 (PubMed).

Colonna, Samaridis: "Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells." in: Science (New York, N.Y.), Vol. 268, Issue 5209, pp. 405-8, 1995 (PubMed).