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  • 产品名称：CD3eMolecule,epsilon(CD3-TCRComplex)(CD3E)(AA23-126)(Active)protein(StrepTag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
CD3eMolecule,epsilon(CD3-TCRComplex)(CD3E)(AA23-126)(Active)protein(StrepTag)
详情介绍：
Characteristics This protein carries a twin strep tag at the C-terminus. The protein has a calculated MW of 14.8 kDa. The protein migrates as 18-22 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >85 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.
Molecular Weight 14.8 kDa
NCBI Accession NP_000724
UniProt P07766
Research Area Stem Cells, Hematopoietic Progenitors, Hematopoietic Stem Cells, Adaptive Immunity, CD Antigens, Surface Receptors of Immune Cells
Pathways TCR Signaling, CXCR4-mediated Signaling Events
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for CD3e Molecule, epsilon (CD3-TCR Complex) (CD3E) (AA 23-126) (Active) protein (Strep Tag) (ABIN2180780) CD3e Molecule, epsilon (CD3-TCR Complex) (CD3E) (AA 23-126) (Active) protein (Strep Tag)
Background publications Arbuckle, Gold, Andres, Schwartzman, Chaikelson: "The role of psychosocial context, age, and intelligence in memory performance of older men." in: Psychology and aging, Vol. 7, Issue 1, pp. 25-36, 1992 (PubMed).