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  • 产品名称：Lysosomal-AssociatedMembraneProtein1(LAMP1)(AA29-382)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
Lysosomal-AssociatedMembraneProtein1(LAMP1)(AA29-382)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 39.2 kDa. The protein migrates as 60-100 kDa under reducing (R) condition (SDS-PAGE) due to different glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
ProductDetails: Biological Activity Comment Biological Activity: Measured by its binding ability in a functional ELISA. When rhLAMP1 /CD107a is coated at 1 μg/mL, rhGalectin-3 (Catalog # GA3-H5129 ) binds with an apparent KD <30 nm.="" <="" td="">
Background Lysosomal-associated membrane protein 1 (LAMP1) is also known as CD107a (Cluster of Differentiation 107a). LAMP1 / CD107a belongs to the LAMP family. This glycoprotein provides selectins with carbohydrate ligands. It may also play a role in tumor cell metastasis. CD107a has also been shown to be a marker of degranulation on lymphocytes such as CD8+ and NK cells.
Molecular Weight 39.2 kDa
NCBI Accession NP_005552
UniProt P11279
Research Area Cancer, Hematopoietic Progenitors, Organelles
Pathways Autophagy
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Lysosomal-Associated Membrane Protein 1 (LAMP1) (AA 29-382) (Active) protein (His tag) (ABIN2181451) Human LAMP1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained ov...
Background publications Carlsson, Lycksell, Fukuda: "Assignment of O-glycan attachment sites to the hinge-like regions of human lysosomal membrane glycoproteins lamp-1 and lamp-2." in: Archives of biochemistry and biophysics, Vol. 304, Issue 1, pp. 65-73, 1993 (PubMed).