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  • 产品名称：Interleukin18BindingProtein(IL18BP)(AA31-194)(Active)protein(Histag)

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  • 产品厂商：ACROBiosystems
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简单介绍：
Interleukin18BindingProtein(IL18BP)(AA31-194)(Active)protein(Histag)
详情介绍：
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 18.5 kDa. The protein migrates as 28-48 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Interleukin-18-binding protein (IL18BP) is also known as Tadekinig-alfa, IL18BPa, which functions as an IL18 inhibitor. IL18BP is a secreted protein which contains one Ig-like C2-type (immunoglobulin-like) domain. IL18BP does not have a transmembrane domain and hence is not anchored to the cell membrane. IL18BP is strongly expressed in heart, lung, placenta and spleen. Isoform A of IL18BP binds to IL-18 and inhibits its activity. IL18BP also functions as an inhibitor of the early TH1 cytokine response. IL18BP suppresses the production of IFN-gamma resulting in reduced T-helper type 1 immune responses.
Molecular Weight 18.5 kDa
NCBI Accession NP_001138529
UniProt O95998
Research Area Cytokines, Immunology, Virology, Inflammation, Cancer
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Interleukin 18 Binding Protein (IL18BP) (AA 31-194) (Active) protein (His tag) (ABIN2181348) Interleukin 18 Binding Protein (IL18BP) (AA 31-194) (Active) protein (His tag)
Background publications Novick, Kim, Fantuzzi, Reznikov, Dinarello, Rubinstein: "Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response." in: Immunity, Vol. 10, Issue 1, pp. 127-36, 1999 (PubMed).

Aizawa, Akita, Taniai, Torigoe, Mori, Nishida, Ushio, Nukada, Tanimoto, Ikegami, Ikeda, Kurimoto: "Cloning and expression of interleukin-18 binding protein." in: FEBS letters, Vol. 445, Issue 2-3, pp. 338-42, 1999 (PubMed).