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  • 产品名称：TumorNecrosisFactorReceptorSuperfamily,Member17(TNFRSF17)(AA1-54)(Active)protei

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  • 产品厂商：ACROBiosystems
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简单介绍：
TumorNecrosisFactorReceptorSuperfamily,Member17(TNFRSF17)(AA1-54)(Active)protein(FcTag)
详情介绍：
Characteristics This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 32 kDa. As a result of glycosylation, the protein migrates as 35-40 kDa under reducing (R) condition, and 66 kDa under non-reducing (NR) condition (SDS-PAGE).
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
ProductDetails: Biological Activity Comment Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized recombinant human BAFF at 1 μg/mL ( 100 μL/well ) can bind rh BCMA /TNFRSF17. The EC50 of human TNFRSF17 is 0.08 μg/mL
Background Tumor necrosis factor receptor superfamily member 17 (TNFRSF17) is also known as B-cell maturation protein (BCMA), CD antigen CD269, which is a member of the TNF-receptor superfamily. TNFRSF17 contains one TNFR-Cys repeat. TNFRSF17 is expressed in mature B-cells, but not in T-cells or monocytes. TNFRSF17 is receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. TNFRSF17 promotes B-cell survival and plays a role in the regulation of humoral immunity. TNFRSF17 can activate NF-kappa-B and JNK.
Molecular Weight 32 kDa
NCBI Accession NP_001183
UniProt Q02223
Research Area Cancer, Growth Factors
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 50 mM Tris, 100 mM Glycine, pH 7.5
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) (AA 1-54) (Active) protein (Fc Tag) (ABIN2180644) Human BCMA, Fc Tag on SDS-PAGE under reducing (R) and no-reducing (NR) conditions. Th...
Binding Studies (Bind) image for Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) (AA 1-54) (Active) protein (Fc Tag) (ABIN2180644) Immobilized Human BCMA, Fc Tag with a linear range of 0.31-1.25 μg/mL.
Background publications Kaufman, Ching, Willis, Mack, Gross, Bulger: "Burst fractures of the lumbar spine in frontal crashes." in: Accident; analysis and prevention, Vol. 59, pp. 153-63, 2013 (PubMed).

Yu, Boone, Delaney, Hawkins, Kelley, Ramakrishnan, McCabe, Qiu, Kornuc, Xia, Guo, Stolina, Boyle, Sarosi, Hsu, Senaldi, Theill: "APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity." in: Nature immunology, Vol. 1, Issue 3, pp. 252-6, 2001 (PubMed).

Gross, Johnston, Mudri, Enselman, Dillon, Madden, Xu, Parrish-Novak, Foster, Lofton-Day, Moore, Littau, Grossman, Haugen, Foley, Blumberg, Harrison, Kindsvogel, Clegg: "TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease." in: Nature, Vol. 404, Issue 6781, pp. 995-9, 2000 (PubMed).

Hatzoglou, Roussel, Bourgeade, Rogier, Madry, Inoue, Devergne, Tsapis et al.: "TNF receptor family member BCMA (B cell maturation) associates with TNF receptor-associated factor (TRAF) 1, TRAF2, and TRAF3 and activates NF-kappa B, elk-1, c-Jun N-terminal kinase, and p38 ..." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 165, Issue 3, pp. 1322-30, 2000 (PubMed).