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  • 产品名称：LymphotoxinbetaReceptor(TNFRSuperfamily,Member3)(LTBR)(AA31-227)(Active)protein

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  • 产品厂商：ACROBiosystems
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简单介绍：
LymphotoxinbetaReceptor(TNFRSuperfamily,Member3)(LTBR)(AA31-227)(Active)protein(FcTag)
详情介绍：
Characteristics This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 48.4 kDa. The protein migrates as 55-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Lymphotoxin-beta receptor (LTBR) is also known as Tumor necrosis factor receptor superfamily member 3 (TNFRSF3), Tumor necrosis factor receptor type III (TNF-RIII), which is a single-pass type I membrane protein containing four TNFR-Cys repeat regions. Except for interacting with HCV core protein, LTBR can not only associate with itself, but also can associate with TRAF3, TRAF4 and TRAF5. As the receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT, LTBR promotes apoptosis via TRAF3 and TRAF5. Furthermore, LTBR may play a role in the development of lymphoid organs.
Molecular Weight 48.4 kDa
NCBI Accession NP_002333
UniProt P36941
Research Area Chromatin and Nuclear Signaling, Apoptosis/Necrosis
Pathways NF-kappaB Signaling
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 50 mM Tris, 100 mM Glycine, pH 7.5
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Lymphotoxin beta Receptor (TNFR Superfamily, Member 3) (LTBR) (AA 31-227) (Active) protein (Fc Tag) (ABIN2181486) Human LTBR, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained over...
Background publications Rooney, Butrovich, Glass, Borboroglu, Benedict, Whitbeck, Cohen, Eisenberg, Ware: "The lymphotoxin-beta receptor is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells." in: The Journal of biological chemistry, Vol. 275, Issue 19, pp. 14307-15, 2000 (PubMed).

Krajewska, Krajewski, Zapata, Van Arsdale, Gascoyne, Berern, McFadden, Shabaik, Hugh, Reynolds, Clevenger, Reed: "TRAF-4 expression in epithelial progenitor cells. Analysis in normal *****, fetal, and tumor tissues." in: The American journal of pathology, Vol. 152, Issue 6, pp. 1549-61, 1998 (PubMed).

Nakano, Oshima, Chung, Williams-Abbott, Ware, Yagita, Okumura: "TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor." in: The Journal of biological chemistry, Vol. 271, Issue 25, pp. 14661-4, 1996 (PubMed).