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  • 产品名称：Interleukin6SignalTransducer(Gp130,OncostatinMReceptor)(IL6ST)(AA23-617)(Active

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  • 产品厂商：ACROBiosystems
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简单介绍：
Interleukin6SignalTransducer(Gp130,OncostatinMReceptor)(IL6ST)(AA23-617)(Active)protein(FcTag)
详情介绍：
Characteristics This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 93.3 kDa. The protein migrates as 120-130 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Background Interleukin-6 receptor subunit beta (IL6ST) is also known as IL-6 receptor subunit beta, IL-6R subunit beta, IL-6R-beta, IL-6RB, Interleukin-6 signal transducer, Membrane glycoprotein 130 (gp130), CD130, Oncostatin-M receptor subunit alpha and Il6st,which is single-pass type I membrane protein. IL6ST /gp130 /CD130 can be found in tissues such as brain, heart, thymus, spleen, kidney, lung and liver and found in all the cell lines tested except BaF-B03.The expression of IL-6ST /gp130 is not restricted to IL6-responsive cells. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. IL6ST /CD130 can bind to IL6 /IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 s, and transduce the signal. IL6ST /GP130 does not bind IL6 and may have a role in embryonic development.
Molecular Weight 93.3 kDa
NCBI Accession NP_034690
UniProt Q00560
Pathways JAK-STAT Signaling, Cellular Glucan Metabolic Process, Autophagy, Smooth Muscle Cell Migration
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 50 mM Tris, 100 mM Glycine, pH 7.5
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) (AA 23-617) (Active) protein (Fc Tag) (ABIN2181397) Mouse gp130, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained ove...
Background publications Wollscheid, Bausch-Fluck, Henderson, OBrien, Bibel, Schiess, Aebersold, Watts: "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins." in: Nature biotechnology, Vol. 27, Issue 4, pp. 378-86, 2009 (PubMed).

Tanaka, Hara, Copeland, Gilbert, Jenkins, Miyajima: "Reconstitution of the functional mouse oncostatin M (OSM) receptor: molecular cloning of the mouse OSM receptor beta subunit." in: Blood, Vol. 93, Issue 3, pp. 804-15, 1999 (PubMed).

Saito, Yoshida, Hibi, Taga, Kishimoto: "Molecular cloning of a murine IL-6 receptor-associated signal transducer, gp130, and its regulated expression in vivo." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 148, Issue 12, pp. 4066-71, 1992 (PubMed).