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  • 产品名称：Mouseanti-ChickenIgMAntibody(FITC)

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  • 产品厂商：Acris-antibodies
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简单介绍：
Mouseanti-ChickenIgMAntibody(FITC)
详情介绍：
Clone M-1
Isotype IgG2b
Background IgM normally constitutes about 10 % of serum immunoglobulins. IgM antibody is prominent in early immune responses to most antigens and is largely confined to plasma due to it's large size. Monomeric IgM is expressed as a membrane bound antibody on the surface of B cells and as a pentamer when secreted by plasma cells. Due to it's high valency IgM is more efficient than other isotypes is binding antigens with repeating epitopes (virus particles and red blood cells) and is more efficient than IgG in activiating the complement pathway. The gene for the mu constant region contains four domains separated by short intervening sequences. IgM measurement yields information about the body's immediate resistance and response to infection as well as information related to specific diseases. Decreased levels are associated with immune deficiency states, hereditary deficiencies, and myeloma. Increased levels can be associated with Waldenstrom's macroglobulinemia, chronic infection and hepatocellular disease.Synonyms: Chicken Immunoglobulin M
Research Area Secondary Antibodies, Immunology
Application Notes Flow Cytometry: < / = 1 μg/10^6 cells.

Other applications not tested.
Otimal dilutions are dependent on conditions and should be determined by the user.
Comment

Excitation/Emission wavelength: 494 nm/514 nm
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer PBS containing 0.09 % Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice Avoid repeated freezing and thawing.
This product is photosensitive and should be protected from light.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or in (aliquots) at -28 °C for longer.
Supplier Images
Flow Cytometry (FACS) image for Mouse anti-Chicken IgM Antibody (FITC) (ABIN371378) Mouse anti-Chicken IgM antibody (FITC)
Background publications Chen, Lehmeyer, Cooper: "Evidence for an IgD homologue on chicken lymphocytes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 129, Issue 6, pp. 2580-5, 1983 (PubMed).