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  • 产品名称：anti-HCVNS5aProteinantibody(FITC)

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  • 产品厂商：BioAcademia
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简单介绍：
anti-HCVNS5aProteinantibody(FITC)
详情介绍：
Immunogen A region of NS5a protein of HCV genotype 1b expressed in E. coli
Clone 8926
Isotype IgG2a kappa
Specificity Specific to human HCV NS5a protein of genotype 1b.
Cross-Reactivity (Details) Not tested in other genotypes.
Purification Purified
Sterility Sterile filtered
Background Hepatitis C virus (HCV) is a small (55-65 nm in size), enveloped, positive sense single-stranded RNA virus in the family Flaviviridae and the principal cause of parenteral non-A, non-B hepatitis. The virus genome consists of a single open reading frame of approximately 9,400 bases which encodes a single polyprotein of about 3,010 amino acids. The polyprotein is processed by host cell and viral proteases into four structural proteins (core, envelope1 and 2, and p7) and six non-structural proteins (NS2, 3, 4a, 4b, 5a, and 5b) necessary for viral replication. The primary function of NS5a is not known, but from the comparative studies with other viruses it is predicted to play a role in RNA replication.
Application Notes 1. Western blotting
2. Immunofluorescence staining
Other applications have not been tested
Restrictions For Research Use only
Format Liquid
Concentration 1.4 mg/mL
Buffer PBS with 50 % Glycerol
Preservative Azide free
Storage -20 °C
Supplier Images
Western Blotting (WB) image for anti-HCV NS5a Protein antibody (FITC) (ABIN2452006) anti-HCV NS5a Protein antibody (FITC)
Immunofluorescence (IF) image for anti-HCV NS5a Protein antibody (FITC) (ABIN2452006) anti-HCV NS5a Protein antibody (FITC) (Image 2)
Product cited in: Manabe, Fuke, Tanishita, Kaji, Gomi, Yoshida, Mori, Takamizawa, Yosida, Okayama: "Production of nonstructural proteins of hepatitis C virus requires a putative viral protease encoded by NS3." in: Virology, Vol. 198, Issue 2, pp. 636-44, 1994 (PubMed).

Takamizawa, Mori, Fuke, Manabe, Murakami, Fujita, Onishi, Andoh, Yoshida, Okayama: "Structure and organization of the hepatitis C virus genome isolated from human carriers." in: Journal of virology, Vol. 65, Issue 3, pp. 1105-13, 1991 (PubMed).

Kato, Hijikata, Ootsuyama, Nakagawa, Ohkoshi, Sugimura, Shimotohno: "Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, Issue 24, pp. 9524-8, 1991 (PubMed).

Choo, Kuo, Weiner, Overby, Bradley, Houghton: "Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome." in: Science (New York, N.Y.), Vol. 244, Issue 4902, pp. 359-62, 1989 (PubMed).