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  • 产品名称：anti-HCVNS4aProtein(N-Term)antibody(Biotin)

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  • 产品厂商：BioAcademia
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简单介绍：
anti-HCVNS4aProtein(N-Term)antibody(Biotin)
详情介绍：
Immunogen A region of NS4 protein of HCV genotype 1b expressed in E. coli. The epitope of this antibody was mapped to the N-terminal region of the NS4 protein (NS4a).
Clone S4-13
Isotype IgG2b kappa
Specificity Specific to human HCV NS4a protein of genotype 1b.
Cross-Reactivity (Details) It does not react with genotypes 1a, and 2a.
Sterility Sterile filtered
Background Hepatitis C virus (HCV) is a small (55-65 nm in size), enveloped, positive sense single-stranded RNA virus in the family Flaviviridae and the principal cause of parenteral non-A, non-B hepatitis. The virus genome consists of a single open reading frame of approximately 9,400 bases which encodes a single polyprotein of about 3,010 amino acids . The polyprotein is processed by host cell and viral proteases into four structural proteins (core, envelope1 and 2, and p7) and six non-structural proteins (NS2, 3, 4a, 4b, 5a, and 5b) necessary for viral replication. NS3 serine proteinase is responsible for proteolytic processing of other non-structural proteins. NS4a protein (54 amino acids) forms a comlex with NS3 and functions as a cofactor for NS3 protease activity.
Application Notes 1. Western blotting
2. Immunofluorescence staining
3. ELISA
Comment

Conjugate: Biotin conjugated, [biotin] / [IgG] = 11.3
Restrictions For Research Use only
Format Liquid
Concentration 0.6 mg/mL
Buffer PBS, 50 % glycerol
Preservative Azide free
Storage -20 °C
Supplier Images
Western Blotting (WB) image for anti-HCV NS4a Protein (N-Term) antibody (Biotin) (ABIN2452000) anti-HCV NS4a Protein (N-Term) antibody (Biotin)
Immunofluorescence (IF) image for anti-HCV NS4a Protein (N-Term) antibody (Biotin) (ABIN2452000) anti-HCV NS4a Protein (N-Term) antibody (Biotin) (Image 2)
Product cited in: Brass, Moradpour, Blum: "Molecular virology of hepatitis C virus (HCV): 2006 update." in: International journal of medical sciences, Vol. 3, Issue 2, pp. 29-34, 2006 (PubMed).

Manabe, Fuke, Tanishita, Kaji, Gomi, Yoshida, Mori, Takamizawa, Yosida, Okayama: "Production of nonstructural proteins of hepatitis C virus requires a putative viral protease encoded by NS3." in: Virology, Vol. 198, Issue 2, pp. 636-44, 1994 (PubMed).

Takamizawa, Mori, Fuke, Manabe, Murakami, Fujita, Onishi, Andoh, Yoshida, Okayama: "Structure and organization of the hepatitis C virus genome isolated from human carriers." in: Journal of virology, Vol. 65, Issue 3, pp. 1105-13, 1991 (PubMed).

Kato, Hijikata, Ootsuyama, Nakagawa, Ohkoshi, Sugimura, Shimotohno: "Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, Issue 24, pp. 9524-8, 1991 (PubMed).