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  • 产品名称：anti-IntercellularAdhesionMolecule3(ICAM3)antibody(PE)

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简单介绍：
anti-IntercellularAdhesionMolecule3(ICAM3)antibody(PE)
详情介绍：
Immunogen Human myeloma cell line (RPMI8226)
Clone YUK2
Isotype IgG1
Specificity This antibody reacts with human CD50 antigen.
Purification Protein A agarose
Alternative Name CD50 / ICAM3 (ICAM3 Antibody Abstract)
Background Intercellular adhesion molecules (ICAMs) are type I transmem brane glycoproteins, which contain 2-9 immunoglobulin-like C2-type domains, and bind to lymphocyte function- associated antigen-1 (LFA-1, also known as a L/ ß 2 or CD11a/CD18). ICAM-3 (CD50) is broadly expressed on leukocytes, endothelial cells, and Langerhans cells. ICAM-3 is the most important ligand for LFA-1 in the initiation of the immune response because the expression of ICAM-1 (CD54) and ICAM-2 (CD102) on resting leukocytes is very low or not at all. Previous studies suggest that ICAM-3 acts as a biologically significant molecule playing a role in HIV-1 transcription and replication, particularly in resting CD4 + T cells. It has been suggested that dendritic cell-specific ICAM grabbing nonintegrin (DC-SIGN, CD209), a C-type lectin of macrophages and DCs, is an additional ligand of ICAM-3. The interaction of DC-SIGN with ICAM-3 establishes initial contact between dendritic cells and resting T-cells during antigen presentation.Synonyms: CDw50, ICAM-3, ICAM-R, Intercellular adhesion molecule 3
Gene ID 3385
NCBI Accession NP_002153
UniProt P32942
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Buffer PBS containing 1 % BSA and 0.09 % NaN3
Storage 4 °C
Storage Comment Store at 2-8 °C.
Supplier Images
Flow Cytometry (FACS) image for anti-Intercellular Adhesion Molecule 3 (ICAM3) antibody (PE) (ABIN1449266) anti-Intercellular Adhesion Molecule 3 (ICAM3) antibody (PE)
Background publications Lazebnik, Cole, Cooke, Nelson, Earnshaw: "Nuclear events of apoptosis in vitro in cell-free mitotic extracts: a model system for analysis of the active phase of apoptosis." in: The Journal of cell biology, Vol. 123, Issue 1, pp. 7-22, 1993 (PubMed).

Fawcett, Holness, Needham, Turley, Gatter, Mason, Simmons: "Molecular cloning of ICAM-3, a third ligand for LFA-1, constitutively expressed on resting leukocytes." in: Nature, Vol. 360, Issue 6403, pp. 481-4, 1992 (PubMed).