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  • 产品名称：anti-CD40antibody(CD40Molecule,TNFReceptorSuperfamilyMember5)(ExtracellularDoma

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  • 产品厂商：BioAcademia
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简单介绍：
anti-CD40antibody(CD40Molecule,TNFReceptorSuperfamilyMember5)(ExtracellularDomain)(FITC)
详情介绍：
Immunogen Recombinant extracellular domain of CD40
Clone 5C3
Isotype IgG1 kappa
Sterility Sterile filtered
Alternative Name CD40 (CD40 Antibody Abstract)
Background CD40 is a 45-50- kDa glycoprotein belonging to the tumor necrosis factor (TNF) receptor superfamily. CD40 is specifically expressed on the surface of B cells and specialized antigen-presenting cells such as dendritic cells and macrophages. CD40 interacts with the CD40 ligand (CD154) which is found primarily on T cells, playing a role in both humoral and cell-mediated immune responses. Activation of CD40 on B cells by CD40 ligand causes B cell proliferation, differentiation, immunoglobulin isotype switching, germinal center formation, and stimulation of the humoral memory response. This antibody reacts with a 45-48 kDa type I integral membrane glycoprotein present on peripheral blood and tonsillar B cells, but not expressed on terminally differentiated B cells. The antibody against human CD40 was produced from hybridoma (5C3) cultured in serum-free medium and purified under mild conditions by proprietary chromatography processes.
UniProt P25942
Research Area Stem Cells, Hematopoietic Progenitors, Adaptive Immunity, CD Antigens, Surface Receptors of Immune Cells, Apoptosis/Necrosis, Inflammation, Cancer
Pathways NF-kappaB Signaling, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
Application Notes 1. Flowcytometry
2. Immunohistochemistry (acetone-fixed fronzen section,)
Comment

Conjugate: [FITC] / [IgG] = 5.5
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS with 50 % Glycerol
Preservative Azide free
Storage -20 °C
Supplier Images
Flow Cytometry (FACS) image for anti-CD40 antibody (CD40 Molecule, TNF Receptor Superfamily Member 5) (Extracellular Domain) (FITC) (ABIN2451935) anti-CD40 Molecule, TNF Receptor Superfamily Member 5 (CD40) (Extracellular Domain) antibody (FITC)
Product cited in: Ishida, Kumanogoh, Suzuki, Akahani, Noda, Kikutani: "Involvement of CD100, a lymphocyte semaphorin, in the activation of the human immune system via CD72: implications for the regulation of immune and inflammatory responses." in: International immunology, Vol. 15, Issue 8, pp. 1027-34, 2003 (PubMed).

Yasui, Muraoka, Takaoka-Shichijo, Ishida, Takegahara, Uchida, Kumanogoh, Suematsu, Suzuki, Kikutani: "Dissection of B cell differentiation during primary immune responses in mice with altered CD40 signals." in: International immunology, Vol. 14, Issue 3, pp. 319-29, 2002 (PubMed).

Inui, Kaisho, Kikutani, Stamenkovic, Seed, Clark, Kishimoto: "Identification of the intracytoplasmic region essential for signal transduction through a B cell activation molecule, CD40." in: European journal of immunology, Vol. 20, Issue 8, pp. 1747-53, 1990 (PubMed).