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  • 产品名称：anti-HCVCoreProtein(AA13-124),(AA369-704)antibody(FITC)

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  • 产品厂商：BioAcademia
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简单介绍：
anti-HCVCoreProtein(AA13-124),(AA369-704)antibody(FITC)
详情介绍：
Immunogen A part of the core region (nucleotides 369-704, aa 13-124) of HCV genotype 1b expressed in E. coli
Clone H6-29
Isotype IgG2a kappa
Specificity Specific to human HCV core antigen of genotype 1b.
Cross-Reactivity (Details) Not tested in other genotypes.
Sterility Sterile filtered
Background Hepatitis C virus (HCV) is a small (55-65 nm in size), enveloped, positive sense single-stranded RNA virus in the family Flaviviridae and the principal cause of parenteral non-A, non-B hepatitis. The virus genome consists of a single open reading frame of approximately 9.4 kb which encodes a single polyprotein of about 3,010 amino acids. The polyprotein is processed by host cell and viral proteases into four structural proteins (core, envelope1 and 2, and p7) and six non-structural proteins (NS2, 3, 4a, 4b, 5a, and 5b) necessary for viral replication. HCV core protein (191 aa) is not only a component of nucleocapsid but also has multiple functions and is thought to be a pathogenic factor for hepatitis. It also participates in some cellular processes, including transcriptional regulation and cellular transduction. HCV core antigen is used as diagnostic marker for HCV infection.
Application Notes 1. Immunofluorescence staining
2. Immunohistochemistry
Comment

Conjugate: FITC conjugated, [FITC] / [IgG] = 6.7
Restrictions For Research Use only
Format Liquid
Concentration 1.6 mg/mL
Buffer PBS with 50 % Glycerol
Preservative Azide free
Storage -20 °C
Supplier Images
Immunohistochemistry (IHC) image for anti-HCV Core Protein (AA 13-124), (AA 369-704) antibody (FITC) (ABIN2451998) anti-HCV Core Protein (AA 13-124), (AA 369-704) antibody (FITC)
Western Blotting (WB) image for anti-HCV Core Protein (AA 13-124), (AA 369-704) antibody (FITC) (ABIN2451998) anti-HCV Core Protein (AA 13-124), (AA 369-704) antibody (FITC) (Image 2)
Immunofluorescence (IF) image for anti-HCV Core Protein (AA 13-124), (AA 369-704) antibody (FITC) (ABIN2451998) anti-HCV Core Protein (AA 13-124), (AA 369-704) antibody (FITC) (Image 3)
Product cited in: Brass, Moradpour, Blum: "Molecular virology of hepatitis C virus (HCV): 2006 update." in: International journal of medical sciences, Vol. 3, Issue 2, pp. 29-34, 2006 (PubMed).

Manabe, Fuke, Tanishita, Kaji, Gomi, Yoshida, Mori, Takamizawa, Yosida, Okayama: "Production of nonstructural proteins of hepatitis C virus requires a putative viral protease encoded by NS3." in: Virology, Vol. 198, Issue 2, pp. 636-44, 1994 (PubMed).

Hiramatsu, Hayashi, Haruna, Kasahara, Fusamoto, Mori, Fuke, Okayama, Kamada: "Immunohistochemical detection of hepatitis C virus-infected hepatocytes in chronic liver disease with monoclonal antibodies to core, envelope and NS3 regions of the hepatitis C virus genome." in: Hepatology (Baltimore, Md.), Vol. 16, Issue 2, pp. 306-11, 1992 (PubMed).

Takamizawa, Mori, Fuke, Manabe, Murakami, Fujita, Onishi, Andoh, Yoshida, Okayama: "Structure and organization of the hepatitis C virus genome isolated from human carriers." in: Journal of virology, Vol. 65, Issue 3, pp. 1105-13, 1991 (PubMed).

Kato, Hijikata, Ootsuyama, Nakagawa, Ohkoshi, Sugimura, Shimotohno: "Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, Issue 24, pp. 9524-8, 1991 (PubMed).