产品详情
所在位置: 首页> 产品目录> 一抗>
查看大图

  • 产品名称：anti-KillerCellLectin-LikeReceptorSubfamilyD,Member1(KLRD1)antibody(PE)

  • 产品型号：
  • 产品厂商：Acris-antibodies
  • 产品文档：
你添加了1件商品 查看购物车
简单介绍：
anti-KillerCellLectin-LikeReceptorSubfamilyD,Member1(KLRD1)antibody(PE)
详情介绍：
Immunogen Murine T cell clone AE7 cells Donor: Lewis Rat spleen cells Fusion Partner: Murine myeloma cell line SP2/0
Clone 15F-18D1
Isotype IgG1
Specificity Anti-mouse CD94 monoclonal antibody detects the mouse CD94 receptor.
Alternative Name CD94 (KLRD1 Antibody Abstract)
Background CD94 is a 180 amino acid, 70 KDa transmembrane glycoprotein that belongs to a family of murine Natural Killer (NK) cell receptors for MHC class I and is co-expressed as a heterodimer with NKG2 on the cellular surface. CD94 is expressed on NK cells as well as NK T cells. Both the murine CD94/NKG2 heterodimer and its human homologue are expressed on Th1 but not Th2 cells. Similar in function to the NKG2 family of receptors, CD94 is involved in NK target cell recognition, functions as an inhibitory receptor and plays an important role in adhesion and activation of the NK cell lineage. The unique expression of the CD94/NKG2 heterodimer on the Th1 subset of activated CD4+ cells suggests the potential use of our CL8950AP antibody in cell differentiation studies.Synonyms: KLRD1, KP43, Killer cell lectin-like receptor subfamily D member 1, NK cell receptor, Natural killer cells antigen CD94
Gene ID 16643
NCBI Accession NP_034784
UniProt O54707
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0,1 mg/mL
Buffer PBS containing 0.02 % sodium azide (NaN3) as preservative and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/mL.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice DO NOT FREEZE!
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.
Background publications Meyers, Ryu, Monney, Nguyen, Greenfield, Freeman, Kuchroo: "Cutting edge: CD94/NKG2 is expressed on Th1 but not Th2 cells and costimulates Th1 effector functions." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 169, Issue 10, pp. 5382-6, 2002 (PubMed).

Toyama-Sorimachi, Taguchi, Yagita, Kitamura, Kawasaki, Koyasu, Karasuyama: "Mouse CD94 participates in Qa-1-mediated self recognition by NK cells and delivers inhibitory signals independent of Ly-49." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 166, Issue 6, pp. 3771-9, 2001 (PubMed).

Vance, Kraft, Altman, Jensen, Raulet: "Mouse CD94/NKG2A is a natural killer cell receptor for the nonclassical major histocompatibility complex (MHC) class I molecule Qa-1(b)." in: The Journal of experimental medicine, Vol. 188, Issue 10, pp. 1841-8, 1999 (PubMed).