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  • 产品名称：anti-DLG3antibody(Discs,LargeHomolog3(Drosophila))(AA1-120)(FITC)

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简单介绍：
anti-DLG3antibody(Discs,LargeHomolog3(Drosophila))(AA1-120)(FITC)
详情介绍：
Immunogen Fusion protein amino acids 1-120 of rat SAP102
Clone S19-2
Isotype IgG1
Specificity Detects ~105 kDa. No cross-reactivity against PSD95, SAP97 or Chapsyn-110.
Purification Protein G Purified
Alternative Name SAP102 (DLG3 Antibody Abstract)
Background Synapse-associated protein 102 belongs to the membrane-associated guanylate kinase protein family and is a homolog of the Drosophila dis large tumor suppressor protein. SAP102 has extensive sequence homology to the PSD 95 family of proteins that facilitate ion channel clustering at synaptic terminal (1, 2). SAP102 consists of three 90 amino acids PDZ domains at its amino terminus, a Src homology 3 domain and a guanylate kinase domain (3). All three PDZ domains of SAP102 participate in binding to the NMDA reception, interacting specifically with the carboxy-terminal domain of the N-methyl-D-aspartate receptor 2B (NR2B). The interaction may facilitate AMPA receptor withdrawal from the postsynaptic membrane by inhibiting the ERK/MAPK pathway (3, 4). SAP102 also interacts with synaptic ras-GTPase activating protein synGAP through its PDZ domains (3). In general, the SAP102 protein is more highly expressed in non-proliferating cells than in proliferating cells, indicating a role in the negative regulation of cell growth.
Gene ID 58948
NCBI Accession NP_113827
UniProt Q62936
Research Area Neurology, Proliferation Markers
Application Notes
  • WB (1:1000)
  • ICC/IF (1:100)
  • optimal dilutions for assays should be determined by the user.
Comment

1 μg/ml was sufficient for detection of Sap102 in 10 μg of rat brain lysate by colorimetric immunoblot analysis using Goat Anti-Mouse IgG:HRP as the secondary.
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
Immunofluorescence (fixed cells) (IF/ICC) image for anti-DLG3 antibody (Discs, Large Homolog 3 (Drosophila)) (AA 1-120) (FITC) (ABIN2482571) Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-SAP102 Monoclonal An...
Western Blotting (WB) image for anti-DLG3 antibody (Discs, Large Homolog 3 (Drosophila)) (AA 1-120) (FITC) (ABIN2482571) Western Blot analysis of Rat brain lysates showing detection of SAP102 protein using ...
Background publications Müller, Kistner, Kindler, Chung, Kuhlendahl, Fenster, Lau, Veh, Huganir, Gundelfinger, Garner: "SAP102, a novel postsynaptic protein that interacts with NMDA receptor complexes in vivo." in: Neuron, Vol. 17, Issue 2, pp. 255-65, 1996 (PubMed).