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  • 产品名称：anti-DBN1antibody(Drebrin1)(N-Term)(PE)

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  • 产品厂商：Acris-antibodies
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简单介绍：
anti-DBN1antibody(Drebrin1)(N-Term)(PE)
详情介绍：
Immunogen Bacterially expressed N-terminal fragment of recombinant human drebrin (aa 1-326).
Clone DBN-N-03
Isotype IgG2b
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Size-Exclusion Chromatography and adjusted for direct use. No reconstitution is necessary
Alternative Name Drebrin (DBN1 Antibody Abstract)
Background Drebrin is an actin-binding protein, which is expressed mainly in neurons and plays important role in their morphogenesis. The highest level of its expression is in developing brain. Both in neurons and non-neuronal cells drebrin acts as a key regulator of actin cytoskeleton remodelling, affecting especially intercellular junctions, such as dendritic spines of neurons or the immune synapses of T cells. Decrease of drebrin amount in the brain seems to be associated with Alzheimer's disease and Down syndrome, and in case of B-cell precursor acute lymphoblastic leukemia (BCP-ALL) lower drebrin expression correlates with higher risk of relapse.Synonyms: D0S117E, DBN-1, DBN1, DKFZp434D064, Developmentally-regulated brain protein, drebrin 1
Gene ID 1627
NCBI Accession NP_004386
Research Area Cancer, Cytoskeleton, Microfilaments, Alzheimer's Disease
Pathways Maintenance of Protein Location
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Buffer PBS, 15 mM Sodium Azide, 0.2 % (w/v) high-grade protease free BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. This products is photosensitive and should be protected from light.
Background publications Vaskova, Kovac, Volna, Angelisova, Mejstrikova, Zuna, Brdicka, Hrusak: "High expression of cytoskeletal protein drebrin in TEL/AML1pos B-cell precursor acute lymphoblastic leukemia identified by a novel monoclonal antibody." in: Leukemia research, Vol. 35, Issue 8, pp. 1111-3, 2011 (PubMed).

Pérez-Martínez, Gordón-Alonso, Cabrero, Barrero-Villar, Rey, Mittelbrunn, Lamana, Morlino, Calabia, Yamazaki, Shirao, Vázquez, González-Amaro, Veiga, Sánchez-Madrid: "F-actin-binding protein drebrin regulates CXCR4 recruitment to the immune synapse." in: Journal of cell science, Vol. 123, Issue Pt 7, pp. 1160-70, 2010 (PubMed).

Hayashi, Ishikawa, Kawai-Hirai, Takagi, Taketomi, Shirao: "Domain analysis of the actin-binding and actin-remodeling activities of drebrin." in: Experimental cell research, Vol. 253, Issue 2, pp. 673-80, 2000 (PubMed).

Sasaki, Hayashi, Shirao, Ishikawa, Kohama: "Inhibition by drebrin of the actin-bundling activity of brain fascin, a protein localized in filopodia of growth cones." in: Journal of neurochemistry, Vol. 66, Issue 3, pp. 980-8, 1997 (PubMed).

Hayashi, Ishikawa, Ye, He, Takata, Kohama, Shirao: "Modulatory role of drebrin on the cytoskeleton within dendritic spines in the rat cerebral cortex." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 16, Issue 22, pp. 7161-70, 1996 (PubMed).

Ishikawa, Hayashi, Shirao, Xue, Takagi, Sasaki, Kohama: "Drebrin, a development-associated brain protein from rat embryo, causes the dissociation of tropomyosin from actin filaments." in: The Journal of biological chemistry, Vol. 269, Issue 47, pp. 29928-33, 1994 (PubMed).