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  • 产品名称：anti-ICAM-1antibody(IntercellularAdhesionMolecule1)(PE)

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  • 产品厂商：Acris-antibodies
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简单介绍：
anti-ICAM-1antibody(IntercellularAdhesionMolecule1)(PE)
详情介绍：
Immunogen Raji cells and spleen cells fused with NS1 cells
Clone 1H4
Isotype IgG2b
Cross-Reactivity (Details) Species reactivity (tested):Human.
Characteristics Synonyms: ICAM-1, Intercellular adhesion molecule 1, Major Group Rhinovirus Receptor
Purification Size-Exclusion Chromatography
Alternative Name CD54 / ICAM1 (ICAM1 Antibody Abstract)
Background CD54 (ICAM-1) is a 90 kD member of the C2 subset of immunoglobulin superfamily. It is a transmembrane molecule with 7 potential N-glycosylated sites, expressed on resting monocytes and endothelial cells and can be upregulated on many other cells, e.g. with lymphokines, on B- and T-lymphocytes, thymocytes, dendritic cells and also on keratinocytes, chondrocytes, as well as epithelial cells. CD54 mediates cell adhesion by binding to integrins CD11a/CD18 (LFA-1) and to CD11b/CD18 (Mac-1). The interaction of CD54 with LFA-1 enhances antigen-specific T-cell activation.Synonyms: ICAM-1, Intercellular adhesion molecule 1, Major Group Rhinovirus Receptor
UniProt P05362
Pathways Cellular Response to Molecule of Bacterial Origin, Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis, Regulation of Leukocyte Mediated Immunity, Thromboxane A2 Receptor Signaling
Application Notes Flow Cytometry: Use 20 μL to label 10^6 cells or 100 μL whole blood or blood or 10^6 cellsin a suspension.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS, 15 mM Sodium Azide, 0.2 % (w/v) high-grade BSA (Protease free)
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
Shelf life: one year from despatch.
Expiry Date 12 months
Supplier Images
Flow Cytometry (FACS) image for anti-ICAM-1 antibody (Intercellular Adhesion Molecule 1) (PE) (ABIN302244) anti-Intercellular Adhesion Molecule 1 (ICAM1) antibody (PE)
Background publications Williams, Chaudhry, Goodfellow, Lea, Evans: "Interactions of decay-accelerating factor (DAF) with haemagglutinating human enteroviruses: utilizing variation in primate DAF to map virus s." in: The Journal of general virology, Vol. 85, Issue Pt 3, pp. 731-8, 2004 (PubMed).

Ockenhouse, Betageri, Springer, Staunton: "Plasmodium falciparum-infected erythrocytes bind ICAM-1 at a site distinct from LFA-1, Mac-1, and human rhinovirus." in: Cell, Vol. 68, Issue 1, pp. 63-9, 1992 (PubMed).

Springer: "Adhesion receptors of the immune system." in: Nature, Vol. 346, Issue 6283, pp. 425-34, 1990 (PubMed).

Boyd, Dunn, Fecondo, Culvenor, Dührsen, Burns, Wawryk: "Regulation of expression of a human intercellular adhesion molecule (ICAM-1) during lymphohematopoietic differentiation." in: Blood, Vol. 73, Issue 7, pp. 1896-903, 1989 (PubMed).

Boyd, Wawryk, Burns, Fecondo: "Intercellular adhesion molecule 1 (ICAM-1) has a central role in cell-cell contact-mediated immune mechanisms." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 85, Issue 9, pp. 3095-9, 1988 (PubMed).