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  • 产品名称：anti-Chemokine(C-CMotif)Ligand2(CCL2)(AA102-130)antibody(Biotin)

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  • 产品厂商：Acris-antibodies
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简单介绍：
anti-Chemokine(C-CMotif)Ligand2(CCL2)(AA102-130)antibody(Biotin)
详情介绍：
Immunogen Synthetic peptide corresponding to residues 102-130 of Mouse MCP-1
Clone ECE-2
Isotype IgG1
Purification Protein G Chromatography
Alternative Name MCP1 / CCL2 (CCL2 Antibody Abstract)
Background The murine JE gene encodes the monocyte-specific cytokine monocyte chemotactic protein 1 (MCP-1). MCP-1 is a CC chemokine of 76 amino acids (~11 kDa) and is chemotactic for monocytes and basophils but not neutrophils and eosinophils. MCP-1 is expressed by smooth muscle cells (SMC), macrophages, endothelial cells, keratinocytes and fibroblasts in response to inflammatory stimuli such as interleukin 1β and tumor necrosis factor α. MCP-1 has been implicated in a variety of inflammatory processes, including inflammatory bowel disease, rheumatoid arthritis, asthma, nephritis, and parasitic and viral infections. MCP-1 antigen is not detected in the endothelium or SMC of normal arteries. MCP-1 has also been shown to exhibit biological activities other than chemotaxis. It can induce the proliferation and activation of killer cells known as CHAK (CC-Chemokine-activated killer) MCP-1 signals via the CCR2 receptor, and is critical for aneurysm formation because of its stability to recruit leukocytes. These leukocytes produce extracellular matrix-degrading MMPs, thereby inductin aortic remodelling and dilatation. Interleukin-6 is also involved in this amplification loop accelerating vascular inflammation. MCP-/- mice display significantly delayed wound re-epithelialization, and also delayed wound angiogenesis.Synonyms: C-C motif chemokine 2, HC-11, HC11, MCAF, MCP-1, Monocyte chemoattractant protein 1, Monocyte chemotactic and activating factor, Monocyte chemotactic protein 1, Monocyte secretory protein JE, SCYA2, Small-inducible cytokine A2
Gene ID 10090
UniProt P10148
Research Area Cytokines, Chemokines
Pathways Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, ER-Nucleus Signaling
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.1 mg/mL
Buffer PBS, 0.02 % Sodium Azide, 0.1 % BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.
Background publications Tieu, Lee, Sun, Lejeune, Recinos, Ju, Spratt, Guo, Milewicz, Tilton, Brasier: "An adventitial IL-6/MCP1 amplification loop accelerates macrophage-mediated vascular inflammation leading to aortic dissection in mice." in: The Journal of clinical investigation, Vol. 119, Issue 12, pp. 3637-51, 2009 (PubMed).

Kimura, Sumiyoshi, Samukawa, Satake, Sakanaka: "Facilitating action of asiaticoside at low doses on burn wound repair and its mechanism." in: European journal of pharmacology, Vol. 584, Issue 2-3, pp. 415-23, 2008 (PubMed).

Zoja, Liu, Donadelli, Abbate, Testa, Corna, Taraboletti, Vecchi, Dong, Rollins, Bertani, Remuzzi: "Renal expression of monocyte chemoattractant protein-1 in lupus autoimmune mice." in: Journal of the American Society of Nephrology : JASN, Vol. 8, Issue 5, pp. 720-9, 1997 (PubMed).